| structure name | INTERMOLECULAR RECOGNITION REVEALED BY THE COMPLEX STRUCTURE OF HUMAN CLOCK-BMAL1 BASIC HELIX-LOOP-HELIX DOMAINS WITH E-BOX DNA (CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT) |
| reference | Su et al. 'Cell 23 213 2013 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=2.40, R-factor=0.198) |
| structural superfamily | HLH, helix-loop-helix DNA-binding domain; |
| sequence family | Helixloophelix DNAbinding domain; |
| multimeric complexes | 4h10_AB |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | RNERR |
Estimated binding specificities ?
| contact |  |
A | 0 96 13 13 C | 96 0 54 13 G | 0 0 16 57 T | 0 0 13 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: CLOCK | ||
| CACGTG | PubMed | 4h10_B(3.59e-04), 4h10_AB(1.18e-09) |
| AACGTGA | PubMed | 4h10_B(1.02e-03), 4h10_AB(3.32e-08) |
| GGCACGAGGC | PubMed | 4h10_B(4.11e-03), 4h10_AB(1.89e-03) |
| CATGTGA | PubMed | 4h10_AB(1.50e-07) |
| CACGTT | PubMed | 4h10_B(3.59e-04), 4h10_AB(8.12e-06) |
| CANNTG | PubMed | 4h10_AB(3.57e-03) |
| CACGNG | PubMed | 4h10_B(3.59e-04), 4h10_AB(7.43e-06) |
| term: circadian locomotor output cycles kaput | ||
| GTGCGTGACA | PubMed | 4h10_B(4.11e-03), 4h10_AB(7.98e-04) |
| GGCACGAGGC | PubMed | 4h10_B(4.11e-03), 4h10_AB(1.89e-03) |
| CACGNG | PubMed | 4h10_B(3.59e-04), 4h10_AB(7.43e-06) |
| CACGTG | PubMed | 4h10_B(3.59e-04), 4h10_AB(1.18e-09) |
| CACGTT | PubMed | 4h10_B(3.59e-04), 4h10_AB(8.12e-06) |
| site | source | matches (E-value) |
Dendrogram of similar interfaces ?
matrix formatRT----NT--RGECRCQT +2ypa_A +-----------------1 ----HGNT----ECRCRG L +---3 +7d8t_A ! ! ----HG------ETRTRG +--4 +-----------------5v0l_A ! ! NTNGRTECRG--RC---- L --5 +---------------------6od3_F ! ----ST------ATRTRG ! +4zpk_B +------------------------2 ----HGNT--MTEARCRG +1nlw_D |
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updated Fri Sep 13 18:18:55 2024