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structure nameANCESTRAL STEROID RECEPTOR 1 IN COMPLEX WITH ESTROGEN RESPONSE ELEMENT DNA
(ANCSR1)
referenceOrtlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=1.70, R-factor=0.176)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes4oln_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYEKAKR

Estimated binding specificities ?

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# IC=2.661 IC/col=0.532 n_of_columns=5 specificity:   
A |   7   2   6   9  42
C |   7   1  11  72  18
G |  64  89   5   6  18
T |  18   4  74   9  18
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----EC--KG----KG----            +-----------------------------4nqa_H    
                                +-9 
  ----EC--KG----RGRG--   L   +-10 +-----------------------------3dzy_D    
                             !  !  
  ----EC--KG----KGRG--       !  +-----------------------------3dzy_A    
                             !  
  ------KG----KGRG----   L   !  +--------------------------2ff0_A    
                           -11  ! 
  --------KAVA--RA----   L   !  !                            +5e69_A    
                             !  !                          +-1 
  ----EA--KG----RTRTRT       !  !                      +---2 +4umm_E    
                             +--8                      !   ! 
  ----EA--KG----RTRTRT          !              +-------5   +2han_B    
                                !              !       ! 
  ----ET--KGAT----RG--   L      !          +---6       +---1lat_A    
                                !          !   ! 
  ----DG--KG----RTRG--   L      !          !   !          +3cbb_A    
                                +----------7   +----------3 
  CA--EC--KG----KGRG--   L                 !              +6l6q_B    
                                           ! 
  --HC----KGVT----RG--                     !             +-3g9m_B    
                                           +-------------4 
  --------KGVT--RG----                                   +-5emp_A    
                           

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updated Fri Sep 13 18:34:48 2024