interface graph thumbnail
legend  pdf

structure nameANCESTRAL STEROID RECEPTOR 1 IN COMPLEX WITH ESTROGEN RESPONSE ELEMENT DNA
(ANCSR1)
referenceOrtlund et al. 'Cell(Cambridge,Mass.)' 159 58 2014
sourceSYNTHETIC CONSTRUCT
experimentX-ray (resolution=1.70, R-factor=0.176)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes4oln_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYEKAKR

Estimated binding specificities ?

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# IC=2.517 IC/col=0.503 n_of_columns=5 specificity:   
A |  18  12  72   2  15
C |  18   8   7  89  67
G |  18  66  10   2   8
T |  42  10   7   3   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----KGVTRG--   L   +-----------------------------2c7a_B    
                     ! 
  --ECKGAGKGRG   L   !                            +1hcq_E    
                     !             +--------------1 
  --ECKGAGRG--   L --5         +---2              +4ond_A    
                     !         !   ! 
  --EAKG--KTRG   L   !      +--3   +---------------4umm_A    
                     !      !  ! 
  --ECKGAGKTRG   L   +------4  +-------------------4aa6_B    
                            ! 
  CAECKG--KGRG   L          +----------------------1cit_A    
                   

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updated Sat Jan 10 07:20:09 2026