interface graph thumbnail
legend  pdf

structure nameKSTR, TRANSCRIPTIONAL REPRESSOR OF CHOLESTEROL DEGRADATION IN MYCOBACTERIUM TUBERCULOSIS, BOUND TO THE DNA OPERATOR
(HTH-TYPE TRANSCRIPTIONAL REPRESSOR KSTR)
referencePodust et al. 'To ? ? ?
sourceMYCOBACTERIUM TUBERCULOSIS
experimentX-ray (resolution=2.26, R-factor=0.205)
structural superfamilyHomeodomain-like;
sequence familyBacterial regulatory proteins, tetR family;
multimeric complexes5fmp_AB 5ua1_AB
redundant complexes5ua1_A 5ua2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureMRAVTY

Estimated binding specificities ?

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# IC=5.010 IC/col=0.716 n_of_columns=7 specificity:   
A |  17  52  24  78  96   0  96
C |  19   8  24   8   0  96   0
G |  17  19  24   8   0   0   0
T |  43  17  24   2   0   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: KSTR
AACTGGAACGTGTTTCAGTTPubMed5fmp_AB(5.12e-12), 5ua1_AB(3.23e-10)
TNNAACNNGTTNNAPubMed5fmp_AB(1.50e-05), 5ua1_AB(9.82e-05)

Dendrogram of similar interfaces ?

matrix format
  
  VT--AGDT--TTYT--   L                         +5gpc_B    
                                             +-1 
  ----TTRG----YT--   L                +------2 +7jnp_A    
                                      !      ! 
  LC--RTPTPTSTYT--   L   +------------3      +6nsn_B    
                         !            ! 
  MTRGTGPT--ATYTWT   L --4            +-------5yej_B    
                         ! 
  ----TGKG----YCFA   L   +--------------------4pxi_B    
                       

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updated Fri Sep 13 19:37:05 2024