interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF BIOQ WITH ITS NATUREL DOUBLE-STRANDED DNA OPERATOR
(TetR family transcriptional regulator)
referenceGuan et al. 'Biochim 1862 1843 2018
sourceMycobacterium smegmatis
experimentX-ray (resolution=2.70, R-factor=0.214)
structural superfamilyTetracyclin repressor-like, C-terminal domain;Homeodomain-like;
sequence familyBacterial regulatory proteins, tetR family; Tetracyclin repressor, Cterminal allalpha 12;
multimeric complexes5yej_BC
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureMRTPAYW

Estimated binding specificities ?

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# IC=7.580 IC/col=0.947 n_of_columns=8 specificity:   
A |   0   0   0   9   7  73  73   0
C |  96   0   0   7  73   7   9   0
G |   0  96   0   7   9   9   7  96
T |   0   0  96  73   7   7   7   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  MTRGTGPT--ATYTWT--------------------   L                           +-----5yej_B    
                                                                     ! 
  VT--AGDT--TTYTLA--------------------   L                   +-------4     +5gpc_B    
                                                             !       !   +-1 
  ----TTRG----YTWA--------------------   L                   !       +---3 +7jnp_A    
                                                          +--5           ! 
  LTRG--PTAC--YT----------------------   L                !  !           +-3lsr_A    
                                                          !  ! 
  MTRGAAVT--TTYT----------------------   L     +----------6  !           +-5fmp_B    
                                               !          !  +-----------2 
  LC--RTPTPTSTYT----------------------   L     !          !              +-6nsn_B    
                                             +-7          ! 
  ----TGKG----YCFA--------------------   L   ! !          +----------------4pxi_B    
                                           --8 ! 
  --------------------------ECRGRCPTRG   L   ! +---------------------------7w27_C    
                                             ! 
  LG--------------TAKGTAHTRG----------   L   +----------------------------6jhe_A    
                                           

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updated Fri Sep 13 21:02:33 2024