5n8o_A : 3D-footprint complex

structure name	CRYO EM STRUCTURE OF THE CONJUGATIVE RELAXASE TRAI OF THE F/R1 PLASMID SYSTEM (DNA HELICASE I)
source	ESCHERICHIA COLI
experiment	NMR
structural superfamily	Origin of replication-binding domain, RBD-like;P-loop containing nucleoside triphosphate hydrolases;
sequence family	TrwC relaxase;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5n8o_A interface=1,194,198,221,290,293,430,500,503,596,598,681,683,791,792,837,1007,1014,1038,1064,1065,1225,1229,1230,1248,1362,1383,1385, MmsiaqvrsagsagnyytdkdnyyvlgsmgerwagkgaeqlglqgsvdkdvftrllegrlpdgadlsrmqdgsnkhrpgydltfsapksvsmmamlggdkrlidahnqavdfavrqvealastrvmtdgqsetvltgnlvmalfnhdtsrdqepqlhthavvanvtqhngewktlssdkvgktgfienvyanqIafgRlyreklkeqvealgyetevvgkHgmwempgvpveafsvdpeirmaewmqtlketgfdirayrdaadqrteirtqapdvqqavtqaiaglseRkvQftytdvlartvgilppengvieraragideaisreqlipldrekglftsgihvldelsvralsrdimkqnrvtvhpeksvprtagysdavsvlaqdrpslaivsgqggaagqrervaelvmmareqgrevqiiaadRrsqmnlkqderlsgelitgrrqllegmaftpgstvivdqgeklslketltlldgaarhnvqvlitdsgqRtgTgsalmamkdagvntyrwqggeqrpatiisepdrnvryarlagdfaasvkageesvaqvsgvreqailtqairselktqgvlghpevtmtalsPvWldsrsrylrdmyrpgmvmeqwnpetrshdryvidrvtaqshsltlrdaqgetqvvrissldsswslfrpekmpvadgerlrvTgKipglrvsggdrlqvasvsedamtvvvpgraepaslpvsdspftalklengwvetpghsvsdsatvfasvtqmamnatlnglarsgrdvrlyssldetrtaeklarhpSFtvvseqikaragetlletaislqkaglhtpaqqaihlalpvlesKnlafsmvdllteaksfaaegtgftelggeinaqikrgdllyvdvakgygtgllvsrasyeaeksilrhilegkeavtplmervpgelmetltsgqraatrmiletsdrftvvqgyagvgkttqfravmsavnmlpaserprvvglgpthravgemrsagvdaqtlasflHdtqlqqRsgetpdfsntlflldessmvgntEmarayaliaagggravasgdtdqlqAIapgqsfrlqqtrsaadvvimkeivrqtpelreavyslinrdveralsglesvkpsqvprlegawapehsvtefshsqeaklaeaqqkamlkgeafpdipmtlyeaivrdytgrtpeareqtlivthlnedrrvlnsmihdarekagelgkeqvmvpvlnTaniRDgelrrlstweknpdalaLvdnvyhriagiskddglitlqdaegntrlispreavaegvtlytpdkirvgtgdrmrftksdrergyvansvwtvtavsgdsvtlsdgqqtrvirpgqeraeqhidlayaitaHgaqgasetfaialegtegnrKlMagfesayvalsrmkqhvqvytdnrqgwtdainnavqkgtahdvlepk
interface signature	MIRHRQRRTPWTKSFKHREAITRDLHKM

Estimated binding specificities ?

contact

# IC=17.293 IC/col=1.081 n_of_columns=16

specificity:

A |   0   0   0   0   0   0  24   9   0   0   0   9   0   0   0   9
C |   0   0   0   0   0   0  24  11   0   0   0  11   0   0   0   9
G |   0   0   0   0   0   0  24   9   0   0   0   9   0   0   0  11
T |  96  96  96  96  96  96  24  67  96  96  96  67  96  96  96  67

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----------------------------VTETRTHTPTVT--   L         +-----------------------------6sjf_D    
                                                       +-3 
  ----------------------------------DT----RT   L       ! +-----------------------------4n0o_E    
                                                     +-4 
  --------------KATT------------------------   L     ! !                    +--------2p7c_B    
                                                     ! +--------------------2 
  ------RGHTSTFT----------------------------   L   +-5                      +--------1vtn_C    
                                                   ! ! 
  --SGAT------------------------------------   L   ! !                            +4rb3_D    
                                                 --6 +----------------------------1 
  ------------------KTPTPGYTRG--------------   L   !                              +4mtd_D    
                                                   ! 
  TT----------------------------------------       +-----------------------------8pw0_A

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updated Sat Jan 10 08:28:24 2026