5u91_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF TRE/LOXLTR COMPLEX (Tre recombinase protein)
reference	Karpinski et al. 'Nucleic 45 9726 2017
source	synthetic construct
experiment	X-ray (resolution=3.10, R-factor=0.211)
structural superfamily	DNA breaking-rejoining enzymes;lambda integrase-like, N-terminal domain;
sequence family	Phage integrase family;
multimeric complexes	5u91_AB 5u91_EF
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5u91_B interface=26,27,29,30,33,72,73,75,76,79,80,83,187,227,229,230,243,245,248,268, padatsdevrknlmdvfrdrpafseHTwEMllSvcrswaawcklnnrkwfpaepedvrdyllhlqarglavKTiQQhlCRlnMlhrrsglprpsdsnavslvmrrirkenvdagertkqalafertdfdqvrslmensdrcqdirnlaflgvayntllriaeiarirvkdisrtdggrmlihigrtKtlvstagvekalslgvtklverwisvsgvaddpnnylfcRvRRygvaapsatsqlStYalQrifeathrliygakddsgqRylawsghsarvgaardmaragvsipeimqaggwttvnsvmnfirnldsetgamvrlled
interface signature	HTEMSKTQQCRMKRRRSYQR

Estimated binding specificities ?

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# IC=10.027 IC/col=0.771 n_of_columns=13

specificity:

A |   0  96  96   0  96  24  11  96   5  56  24  24  11
C |   0   0   0   0   0  24   5   0  11  13  24  24   7
G |   0   0   0   0   0  24  67   0   1  16  24  24  73
T |  96   0   0  96   0  24  13   0  79  11  24  24   5

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Dendrogram of similar interfaces ?

matrix format

  
  HTTAECMAST--KTTTQTQT--CTRAMT--KA--RARTRCSA--YA--QG--------RA----   L                                +5u91_B    
                                                                                  +-------------------1 
  HTTTKGMTST--KATT--QT----QT----KA--RARTKTST--RG--EA--------RA----           +----2                   +1xo0_B    
                                                                             !    ! 
  NATA----RTTT--NA--RASA--------------------ATVTDT--------RC--NTMT   L     +-4    +-------------------6en1_A    
                                                                           ! ! 
  ----------------------------------------TTQAATYGYAKT----------TT   L   +-5 +------------------------5jk0_B    
                                                                         ! ! 
  --------------------------------KT------------------TT----------   L --6 +--------------------------2b9s_A    
                                                                         ! 
  ----------------------------KC------------------RGST--KT--------   L   !   +-----------------------1flo_A    
                                                                         +---3 
  ----------------------------------------RT--ET------------------           +-----------------------6gys_E

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updated Wed Dec 18 02:23:30 2024