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structure nameCRYSTAL STRUCTURE OF TRE/LOXLTR COMPLEX
(Tre recombinase protein)
referenceKarpinski et al. 'Nucleic 45 9726 2017
sourcesynthetic construct
experimentX-ray (resolution=3.10, R-factor=0.211)
structural superfamilyDNA breaking-rejoining enzymes;lambda integrase-like, N-terminal domain;
sequence familyPhage integrase family;
multimeric complexes5u91_AB 5u91_EF
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHTEMSKTQQCRMKRRRSYQR

Estimated binding specificities ?

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# IC=9.953 IC/col=0.766 n_of_columns=13 specificity:   
A |  12  24  24  12  72   0   6  24   0  96   0   0  96
C |  66  24  24  12  12   0  72  24   0   0   0   0   0
G |   6  24  24   6   6   0  12  24   0   0   0   0   0
T |  12  24  24  66   6  96   6  24  96   0  96  96   0
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Dendrogram of similar interfaces ?

matrix format
  
  HTTAECMAST--KTTTQTQT--CTRAMT--KA--RARTRCSA--YA--QG--------RA----   L                                +5u91_B    
                                                                                  +-------------------1 
  HTTTKGMTST--KATT--QT----QT----KA--RARTKTST--RG--EA--------RA----           +----2                   +1xo0_B    
                                                                             !    ! 
  NATA----RTTT--NA--RASA--------------------ATVTDT--------RC--NTMT   L     +-4    +-------------------6en1_A    
                                                                           ! ! 
  ----------------------------------------TTQAATYGYAKT----------TT   L   +-5 +------------------------5jk0_B    
                                                                         ! ! 
  --------------------------------KT------------------TT----------   L --6 +--------------------------2b9s_A    
                                                                         ! 
  ----------------------------KC------------------RGST--KT--------   L   !   +-----------------------1flo_A    
                                                                         +---3 
  ----------------------------------------RT--ET------------------           +-----------------------6gys_E    
                                                                       

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updated Fri Sep 13 20:32:34 2024