6f59_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HUMAN BRACHYURY (T) G177D VARIANT IN COMPLEX WITH DNA (Brachyury protein)
reference	Burgess-Brown et al. 'To ? ? ?
source	Homo sapiens
experiment	X-ray (resolution=2.15, R-factor=0.223)
structural superfamily	p53-like transcription factors;
sequence family	Tbox;
multimeric complexes	6f58_AB 6f59_AB
redundant complexes	6f58_A 8cdn_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6f59_B interface=30,157,158,174,177,178, gelrvgleeselwlrfkeltnemivtkngRrmfpvlkvnvsgldpnamysflldfvaadnhrwkyvngewvpggkpepqapscvyihpdspnfgahwmkapvsfskvkltnklngggqimlnslhkyeprihivrvgdpqrmitshcfpetqfiavTAyqneeitalkikynpFakAFldakers
interface signature	RTAFAF

Estimated binding specificities ?

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# IC=3.142 IC/col=0.449 n_of_columns=7

specificity:

A |  16  24  24  24   0  96  13
C |  13  24  24  24  96   0  57
G |  13  24  24  24   0   0  13
T |  54  24  24  24   0   0  13

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RGTTATFTACFG   L                       +6f59_B    
                                       +-1 
  RGTTATFT--FG                       +-2 +1xbr_B    
                                     ! ! 
  RGTCSCFT--FG          +------------3 +-2x6v_A    
                        !            ! 
  RGTC--FG--FT   L   +--4            +--5flv_I    
                     !  ! 
  RGTT--FG--FT     --5  +---------------5t1j_B    
                     ! 
  RGTTATFG--FG       +------------------4a04_B

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updated Sun Aug 3 11:14:36 2025