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structure nameCRYSTAL STRUCTURE OF TFAM (MITOCHONDRIAL TRANSCRIPTION FACTOR A) BRIDGING TWO NON-SEQUENCE SPECIFIC DNA SUBSTRATES
(Transcription factor A, mitochondrial)
referenceGarcia-Diaz et al. 'Nucleic 50 322 2022
sourceHomo sapiens
experimentX-ray (resolution=2.84, R-factor=0.200)
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
multimeric complexes6erp_ACF 6erp_BGJ 6erq_ACF 6erq_BGJ 7lbw_AB
reference complex3tmm_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSYLSLTTIMKRYNVFPQL

Estimated binding specificities ?

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# IC=13.234 IC/col=0.473 n_of_columns=28 specificity:   
A |  56   0   0   0   0  24  24  65   4  24  24  24  24  24  24  24  24  24  24  24  24  82   9  24  96  96   0   0
C |  13   0  96   0  96  24  24  15   6  24  24  24  24  24  24  24  24  24  24  24  24   4  13  24   0   0   0   0
G |  13  96   0   0   0  24  24   8  82  24  24  24  24  24  24  24  24  24  24  24  24   4  61  24   0   0  96  96
T |  14   0   0  96   0  24  24   8   4  24  24  24  24  24  24  24  24  24  24  24  24   6  13  24   0   0   0   0
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updated Fri Jan 9 13:25:45 2026