interface graph thumbnail
legend  pdf

structure nameTFAM IMPOSES A U-TURN ON MITOCHONDRIAL DNA
(Transcription factor A, mitochondrial)
referenceKaiser et al. Nat.Struct.Mol.Biol. 18 1290 2011
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=0.197)
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKSYLSLTTIMKRYNVFPQL

Estimated binding specificities ?

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# IC=11.222 IC/col=0.660 n_of_columns=17 specificity:   
A |  96   0  79   5  24   5  24  24  24  24  24   0   0  96  91   5   5
C |   0  96   5   7  24  73  24  24  24  24  24  96  96   0   0  79   5
G |   0   0   7  79  24   7  24  24  24  24  24   0   0   0   5   5   7
T |   0   0   5   5  24  11  24  24  24  24  24   0   0   0   0   7  79
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KASTYGLASGLA--TGTCIT--KGRTYANTVTFGPGQC--LC   L                                 +3tmm_A    
                                                         +-----------------------1 
  --STYGLCSGLAKTTGTCIGMGKGRTYANTVTFGPGQC--LC           +-3                       +7lbx_A    
                                                       ! ! 
  RCNTFTMA--RAHGNAACST----------------------   L     +-4 +-----------------------4euw_A    
                                                     ! ! 
  RTNGFTIA--RA--NASGST----------------------   L   +-5 +-------------------------1j46_A    
                                                   ! ! 
  RCNGFTMA--RTHTNG--ST----------------------   L --6 +--------------------------6t90_L    
                                                   ! 
  RGNTFTMA--RT--NGRTSA----------------------   L   !           +---------------7m5w_A    
                                                   +-----------2 
  ------------------------RCFAFTCG--IC--VGAG   L               +---------------2gzk_A    
                                                 

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updated Fri Sep 13 17:42:46 2024