3tmm_A : 3D-footprint complex

structure name	TFAM IMPOSES A U-TURN ON MITOCHONDRIAL DNA (Transcription factor A, mitochondrial)
reference	Kaiser et al. Nat.Struct.Mol.Biol. 18 1290 2011
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=0.197)
structural superfamily	HMG-box;
sequence family	HMG high mobility group box;
multimeric complexes	6erp_ACF 6erp_BGJ 6erq_ACF 6erq_BGJ 7lbw_AB
redundant complexes	7lbw_B 7lbx_B 6erp 6erq
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3tmm_A interface=10,13,15,16,19,23,35,36,39,101,105,115,120,121,124,128,136,137,140, ssvlascpkKpvSsYLrfSkeqLpifkaqnpdakTTelIrriaqrwrelpdskkkiyqdayraewqvykeeisrfkeqltpsqimslekeimdkhlkrkaMtkkKeltllgkpkRprsaYNvyVaerFqeakgdsPQekLktvkenwknlsdsekelyiqhakedetryhnemksweeqmievgrkdllrrtikk
interface signature	KSYLSLTTIMKRYNVFPQL

Estimated binding specificities ?

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# IC=11.631 IC/col=0.684 n_of_columns=17

specificity:

A |  66   0   0   0   0   0  24  24  24  24  24   7  24   7   0   0   0
C |  16   0   7   0   0   0  24  24  24  24  24  14  24  75   0   0   0
G |   7  89   1   0  96  96  24  24  24  24  24  68  24   7   0  96   0
T |   7   7  88  96   0   0  24  24  24  24  24   7  24   7  96   0  96

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Dendrogram of similar interfaces ?

matrix format

  
  KASTYGLASGLA--TGTCIT--KGRTYANTVTFGPGQC--LC   L                                 +3tmm_A    
                                                         +-----------------------1 
  --STYGLCSGLAKTTGTCIGMGKGRTYANTVTFGPGQC--LC           +-3                       +7lbx_A    
                                                       ! ! 
  RCNTFTMA--RAHGNAACST----------------------   L     +-4 +-----------------------4euw_A    
                                                     ! ! 
  RTNGFTIA--RA--NASGST----------------------   L   +-5 +-------------------------1j46_A    
                                                   ! ! 
  RCNGFTMA--RTHTNG--ST----------------------   L --6 +--------------------------6t90_L    
                                                   ! 
  RGNTFTMA--RT--NGRTSA----------------------   L   !           +---------------7m5w_A    
                                                   +-----------2 
  ------------------------RCFAFTCG--IC--VGAG   L               +---------------2gzk_A

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updated Sat Jan 10 06:28:51 2026