7qxb_P : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.

Dendrogram of similar interfaces ?

matrix format

structure name	CRYO-EM MAP OF HUMAN TELOMERASE-DNA-TPP1-POT1 COMPLEX (SHARPENED MAP)
reference	van Roon et al. Science 375 1173 2022
experiment	X-ray (resolution=3.91, R-factor=0.325)
structural superfamily	Nucleic acid-binding proteins;
sequence family	Telomerebinding protein alpha subunit, cen;
multimeric complexes	7qxb_AP 7qxs_AP
redundant complexes	7qxs_P
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7qxb_P interface=26,36,37,57,84,123,185,218,223, atnyiytplnqlkggtivnvygvvkFfkppylskgTDycsvvtivdqtnvkltcllFsgnyealpiiykngdivrfhrlkiqvYkketqgitssgfasltfiprtsskyfnflklcdvqpmqYfdltcqllgkaevdgasfllkvwdgtrtpfpswrvliqdlvlegdlshihrlqnltidilvYdnhvhvarslkvgsflriyslhtkllslefhlHggtsYgrgirvlpesnsdvdqlkkdlesanlta

  
  ----------------------------------------------KG--WGYT--------YCFA------SGSGRGRTIGWGDGDTHTLTYAEG--   L                +----------------4hja_A    
                                                                                                           +------------1 
  ------------------------------------------TGYG--SG--DGKGATFTSGVG--NGYTLG------KG----------------RT   L   !            +----------------1s40_A    
                                                                                                         --3 
  ------YTFT----------NT--SGWGKGFGEGKGKGEGTG--------------------------------------------------------       !        +--------------------3u58_C    
                                                                                                           +--------2 
  RTTTKT----TTATNTTTATFTNT--------------------------------------------------------------------------   L            +--------------------6bhx_B

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updated Sat Sep 14 04:29:17 2024