interface graph thumbnail
legend  pdf

structure nameCAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR N6-BENZYLADENOSINE (COMPOUND 1)
(Site-specific DNA-methyltransferase adenine-specific)
referenceHorton et al. J.Med.Chem. 66 934 2023
sourceClostridioides difficile 630
experimentX-ray (resolution=2.61, R-factor=0.190)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyN6 DNA Methylase 1702;
multimeric complexes8cxs_AB 8cxt_AB 8cxu_AB 8cxv_AB 8cxw_AB 8cxx_AB 8cxy_AB 8cxz_AB 8cy0_AB 8cy1_AB 8cy2_AB 8cy3_AB 8cy4_AB 8cy5_AB 8fs1_AB 8fs2_AB
reference complex8cxy_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYNYHKDKYFNIVQISREIQWRYKSADYMSIY

Estimated binding specificities ?

contactlogo
# IC=9.073 IC/col=1.134 n_of_columns=8 specificity:   
A |  14   0   0   0   0   0   0  85
C |  52   0   0   0   0   0   0   5
G |  16   0   0   0   0   0  96   3
T |  14  96  96  96  96  96   0   3
scan!

home
updated Mon Jun 29 06:31:18 2026