Estimated binding specificities ?

structure nameCAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND COMPOUND 3
(Site-specific DNA-methyltransferase adenine-specific)
referenceHorton et al. J.Med.Chem. 66 934 2023
sourceClostridioides difficile 630
experimentX-ray (resolution=2.26, R-factor=0.182)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyN6 DNA Methylase 1670;
multimeric complexes8cxs_AB 8cxt_AB 8cxu_AB 8cxv_AB 8cxw_AB 8cxx_AB 8cxy_AB 8cxz_AB 8cy0_AB 8cy1_AB 8cy2_AB 8cy3_AB 8cy4_AB 8cy5_AB 8fs1_AB 8fs2_AB
reference complex8cxy_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
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# IC=9.764 IC/col=1.085 n_of_columns=9 specificity:   
A |  16   0   0  96  96  96  96  96  13
C |  13   0  96   0   0   0   0   0  13
G |  13   0   0   0   0   0   0   0  54
T |  54  96   0   0   0   0   0   0  16
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updated Mon Jun 29 06:31:52 2026