8cxw_A : 3D-footprint complex

structure name	CAMA ADENINE METHYLTRANSFERASE COMPLEXED TO COGNATE SUBSTRATE DNA AND INHIBITOR PICLIDENOSON (COMPOUND 4) (Site-specific DNA-methyltransferase adenine-specific)
reference	Horton et al. J.Med.Chem. 66 934 2023
source	Clostridioides difficile 630
experiment	X-ray (resolution=2.78, R-factor=0.186)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
sequence family	N6 DNA Methylase 1791;
multimeric complexes	8cxs_AB 8cxt_AB 8cxu_AB 8cxv_AB 8cxw_AB 8cxx_AB 8cxy_AB 8cxz_AB 8cy0_AB 8cy1_AB 8cy2_AB 8cy3_AB 8cy4_AB 8cy5_AB 8fs1_AB 8fs2_AB
reference complex	8cxy_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cxw_A interface=1,131,134,137,138,158,159,187,219,221,222,224,312,315,345,391,392,397,404,405,407,421,422,438,439,440,442,479,480,483,487, YytpkiivdyivkktlknhdiiknpyprildiscgcgnfllevydilydlfeeniyelkkkydenywtvdnihrhilnyciygadidekaisilkdsltnkkdesdikinlfccdslkkkwrykfdyivgNppYigHKklekkykkfllekysevykDKadlyfcfykkiidilkqggigsvitprYfleslsgkdlreyiksnvnvqeivdflganiFkNIgVssciltfdkkktketyidvfkiknedicinkfetleellksskfehfninqrllsdewilvnkddetfynkiqekckyslediaisfQgiItgcdkafilskddvklnlvddkflkcwikSkninkyivdkseyrliysndidnentnkrildeiiglyktklenrREcksgIrkwyelQWgReklfferkkimypYKsnenrfaidydnnfsSADvYsffikeeyldkfsyeylvgilnssvydkyfkitakkMSknIydyYpnkvmkirifrdnnyeeienlskqiisillnksidkgkveklqikmdnlimdslgi
interface signature	YNYHKDKYFNIVQISREIQWRYKSADYMSIY

Estimated binding specificities ?

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# IC=9.764 IC/col=0.814 n_of_columns=12

specificity:

A |  16  24  24  24  13   0   0   0   0   0   0  96
C |  13  24  24  24  54   0   0   0   0   0   0   0
G |  54  24  24  24  13   0   0   0   0   0  96   0
T |  13  24  24  24  16  96  96  96  96  96   0   0

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updated Mon Jun 29 06:31:58 2026