8ik5_C : 3D-footprint complex

structure name	TRANSCRIPTION FACTOR LMX1A HOMEOBOX DOMAIN IN COMPLEX WITH WNT1 PROMOTER (LMX1A factor)
reference	Lin et al. 'Febs ? ? 2024
source	Homo sapiens
experiment	X-ray (resolution=1.99, R-factor=0.208)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
redundant complexes	8ike_C 8ilw_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8ik5_C interface=10,48,51,52,55,56,58, hmhkrpkrpRtilttqqrrafkasfevsskpcrkvretlaaetglsvRvvQVwfQNqRakmkklarr
interface signature	RRQVQNR

Estimated binding specificities ?

contact

# IC=1.569 IC/col=0.314 n_of_columns=5

specificity:

A |  11  29  67   5  17
C |  11  22   9   7  43
G |  13  21  11   5  19
T |  61  24   9  79  17

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RART------------VTKGNA------KA   L     +-----------------------------2lkx_A    
                                         ! 
  --RT----------QTVAQTNA--------   L     !                            +8osb_E    
                                       +-4                          +-1 
  --RT------------IAQCNA----MG--   L   ! !        +-----------------2 +1b72_A    
                                       ! !        !                 ! 
  ----------------NCICNARGRG----   L --5 +--------3                 +--4xrm_B    
                                       !          ! 
  --RC------------IAQCNA----YC--   L   !          +--------------------3rkq_B    
                                       ! 
  ----AALAITHTKT----------------       +-----------------------------2ofi_A

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updated Mon Aug 4 01:15:35 2025