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legend  pdf

structure nameTRANSCRIPTION FACTOR LMX1A HOMEOBOX DOMAIN IN COMPLEX WITH WNT1 PROMOTER
(LMX1A factor)
referenceLin et al. 'Febs ? ? 2024
sourceHomo sapiens
experimentX-ray (resolution=1.99, R-factor=0.208)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes8ike_C 8ilw_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRQVQNR

Estimated binding specificities ?

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# IC=1.591 IC/col=0.318 n_of_columns=5 specificity:   
A |  11  30  67   5  17
C |  11  23   9   7  43
G |  12  19  11   5  19
T |  62  24   9  79  17
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RART------------VTKGNA------KA   L                               +-2lkx_A    
                                                        +----------3 
  ----------------NCITNA----RGRG   L                    !          ! +6fqq_E    
                                                 +------5          +-1 
  ----RT----------NT--NA----IARG   L             !      !            +4cyc_B    
                                                 !      ! 
  --RC------------IAQCNA----YC--   L             !      +------------3rkq_B    
                                       +---------6 
  --RT----------QTVAQTNA--------   L   !         !                  +8osb_E    
                                       !         !                +-2 
  --RT------------IAQCNA----MG--   L --7         +----------------4 +1b72_A    
                                       !                          ! 
  ----------------NCICNARGRG----   L   !                          +--4xrm_B    
                                       ! 
  ----AALAITHTKT----------------       +-----------------------------2ofi_A

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updated Tue Jun 30 16:52:43 2026