interface graph thumbnail
legend  pdf

structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T)
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.227)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 39;
multimeric complexes1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex8pi8_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTRYNK

Estimated binding specificities ?

readout + contactlogo
# IC=10.914 IC/col=0.780 n_of_columns=14 specificity:   
A |   0  84   0   0  96  24  24  16  12   0  12  96  24  96
C |   0   0   0   0   0  24  24  56   8   4   0   0  24   0
G |  96  12   0   4   0  24  24   8  16  12   8   0  24   0
T |   0   0  96  92   0  24  24  16  60  80  76   0  24   0
scan!

home
updated Sun Aug 3 02:26:11 2025