8pi7_A : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T) (Hepatocyte nuclear factor 1-alpha)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=3.20, R-factor=0.227)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Hepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 39;
multimeric complexes	1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pi7_A interface=51,52,53,54,56,57,63,94,156,161,164, enlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTpmktqkraalytwyvrkqrevaqqfthagnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYnwfaNrrKeeaf
interface signature	NQSHSQTRYNK

Estimated binding specificities ?

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# IC=10.611 IC/col=0.758 n_of_columns=14

specificity:

A |   0  24   0  64  76  60  12  24  24   0  76  96   0   0
C |   0  24   0  12  12  16  16  24  24   0   8   0   0  96
G |   0  24   0   8   8   8  68  24  24   0   4   0   0   0
T |  96  24  96  12   0  12   0  24  24  96   8   0  96   0

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updated Sat Jan 10 01:00:19 2026