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structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T)
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.227)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 39;
multimeric complexes1ic8_AB
reference complex8pi8_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTRYNK

Estimated binding specificities ?

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# IC=10.849 IC/col=0.775 n_of_columns=14 specificity:   
A |   0  79   0   6  96  24  24  14  13   1  14  96  24  96
C |   0   0   0   8   0  24  24  69   9   0   0   0  24   0
G |  96  13   0   4   0  24  24   0  13   4   8   0  24   0
T |   0   4  96  78   0  24  24  13  61  91  74   0  24   0
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updated Fri Sep 13 12:54:21 2024