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structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -169C>T)
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=3.20, R-factor=0.227)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 39;
multimeric complexes1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex8pi8_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTRYNK

Estimated binding specificities ?

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# IC=10.761 IC/col=0.769 n_of_columns=14 specificity:   
A |   0  84   0   4  96  24  24  12  12   4  12  96  24  96
C |   0   4   0   4   0  24  24  75   8   4   0   0  24   0
G |  96   4   0   5   0  24  24   1  14   9   9   0  24   0
T |   0   4  96  83   0  24  24   8  62  79  75   0  24   0
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updated Tue Dec 17 19:02:54 2024