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structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>A)
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.237)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 08;
multimeric complexes1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex8pi8_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTRYNK

Estimated binding specificities ?

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# IC=9.453 IC/col=0.675 n_of_columns=14 specificity:   
A |   0  84   6   0   3  24   3   6  24  84  24   3  24  84
C |   0   6  84   3  84  24   3   3  24   3  24   3  24   3
G |   0   3   3   1   6  24   6   3  24   3  24  87  24   3
T |  96   3   3  92   3  24  84  84  24   6  24   3  24   6
scan!

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updated Sun Aug 3 02:26:25 2025