8pia_B : 3D-footprint complex

structure name	DNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>T) (Hepatocyte nuclear factor 1-alpha)
reference	Myllykoski et al. 'JCI 9 ? 2024
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=0.248)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Hepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 04;
multimeric complexes	1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8pia_B interface=47,48,49,50,53,90,152,153,157,160, peeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlsQhlnkgtpmktqkraalytwyvrkqrevaqqftharnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHQRYNNK

Estimated binding specificities ?

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# IC=2.089 IC/col=0.209 n_of_columns=10

specificity:

A |   8  66  19  10  24  24  20  13  52  60
C |  10  10  38  10  24  24  22  14  16  12
G |   8  10  19  13  24  24  20  13  14  12
T |  70  10  20  63  24  24  34  56  14  12

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updated Sat Jan 10 01:00:41 2026