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structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA VARIANT (P2 -181G>T)
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.248)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 04;
multimeric complexes1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex8pi8_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHQRYNNK

Estimated binding specificities ?

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# IC=8.128 IC/col=0.813 n_of_columns=10 specificity:   
A |   0   0  96  42  24  24  96  21   0  96
C |   0   0   0  10  24  24   0  21   0   0
G |   0   0   0  23  24  24   0  33   0   0
T |  96  96   0  21  24  24   0  21  96   0
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updated Tue Dec 17 19:03:22 2024