| structure name | STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 (RETINOIC ACID RECEPTOR ALPHA) |
| reference | Khorasanizadeh et al. 'EMBO 19 1045 2000 |
| source | HOMO SAPIENS |
| experiment | X-ray (resolution=1.70, R-factor=0.201) |
| structural superfamily | Glucocorticoid receptor-like DNA-binding domain; |
| sequence family | Zinc finger, C4 type two domains; |
| multimeric complexes | 1dsz_AB 6xwg_CD |
| redundant complexes | 6xwg |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | EKRR |
Estimated binding specificities ?
| readout + contact |  |
A | 0 0 16 0 54 C | 0 0 13 96 16 G | 96 96 13 0 13 T | 0 0 54 0 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: RAR | ||
| TGACC | PubMed | 1dsz_A(2.59e-08), 1dsz_AB(1.44e-05), 6xwg_D(1.20e-03) |
| TGATGTCA | PubMed | 1dsz_A(1.79e-03) |
| AGGTCA | PubMed | 1dsz_A(1.21e-07), 1dsz_AB(1.67e-04), 6xwg_CD(2.53e-03), ... (total=4) |
Dendrogram of similar interfaces ?
matrix formatEAKG--RTRTRT +---4umm_E +-----------7 ECKG--KGRG-- L ! +---2ff0_A +------9 DGKG--RTRG-- L ! ! +3cbb_A ! +---------------1 ECKG--KGRG-- ! +3dzy_A ! ECKG--RGRG-- L ! +---2nll_B +---12 +-----6 --KGVT--RG-- L ! ! ! +---5cbz_E ! ! +-------8 ECKG--KGRG-- L ! ! ! ! +1ynw_B ! ! ! +---------3 ECKG--RGRG-- L ! ! ! +3dzy_D ! +---11 EAKG--KTRG-- L ! ! +2han_A -13 ! +---------------2 ECKA--RGRG-- L ! ! ! +4nqa_I ! +-10 --KGVT--RG-- ! ! +1r4i_A ! ! +-4 ETKGAT--RG-- L ! +-------------5 +1lat_A ! ! ECKG--KTRG-- L ! +-2nll_A ! ECKG--RGRG-- L +---------------------------5uan_B |
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updated Fri Sep 13 15:31:45 2024