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structure nameHOMEODOMAIN FROM THE DROSOPHILA PAIRED PROTEIN BOUND TO A DNA OLIGONUCLEOTIDE
(PAIRED PROTEIN)
referenceWilson et al. 'Cell(Cambridge,Mass.)' 82 709 1995
sourceDrosophila melanogaster
experimentX-ray (resolution=2.00, R-factor=0.198)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes1pdn_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVQN

Estimated binding specificities ?

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# IC=5.379 IC/col=0.768 n_of_columns=7 specificity:   
A |   9   0  96  96   9  24  67
C |   9   0   0   0   9  24  11
G |  69   0   0   0   9  24   9
T |   9  96   0   0  69  24   9
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Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PAIRED
GTTATPubMed1fjl_B(6.06e-03)
TAATTPubMed1fjl_B(1.01e-03)
TAATGTTATTAPubMed1fjl_B(1.06e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --RART----VTKGNA--KA   L                               +2lkx_A    
                                                       +-1 
  RA--RA----IAQTNA----   L          +------------------3 +5ego_B    
                                    !                  ! 
  ----RT----NT--NAIARG   L          !                  +1b72_B    
                             +------7 
  ----RT----IAQCNAMG--   L   !      !              +----1b72_A    
                             !      !      +-------5 
  ----RC----IAQCNAYC--   L   !      !      !       +----3rkq_B    
                             !      +------6 
  ----RT--QTVAQTNA----   L --8             !         +--8osb_E    
                             !             +---------4 
  ----------NCICNARGRG   L   !                       !  +4xrm_B    
                             !                       +--2 
  ------RT--NT--NAIARG   L   !                          +4cyc_B    
                             ! 
  ----------VTCCNAQA--   L   +--------------------------8g87_X    
                           

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updated Sat Jan 10 04:36:39 2026