interface graph thumbnail
legend  pdf

structure nameFADR, FATTY ACID RESPONSIVE TRANSCRIPTION FACTOR FROM E. COLI IN COMPLEX WITH FADB OPERATOR
(FATTY ACID METABOLISM REGULATOR PROTEIN)
referenceVan Aalten et al.
sourceESCHERICHIA COLI
experimentX-ray (resolution=3.25, R-factor=0.265)
structural superfamilyFatty acid responsive transcription factor FadR, C-terminal domain;"Winged helix" DNA-binding domain;
sequence familyFadR Cterminal domain; Bacterial regulatory proteins, gntR family;
multimeric complexes1h9t_AB 1hw2_AB
redundant complexes1hw2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRTRTREH

Estimated binding specificities ?

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# IC=4.231 IC/col=0.705 n_of_columns=6 specificity:   
A |  24   0   0  12  24   0
C |  24   0   0  12  24  96
G |  12  96  96  24  24   0
T |  36   0   0  48  24   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FADR
ATCTGGTACGACCAGATPubMed1h9t_B(1.91e-03), 1h9t_AB(2.93e-13), 1hw2_AB(2.86e-12), ... (total=4)
TGGTCTTACCAPubMed1h9t_AB(6.21e-11), 1hw2_AB(5.16e-10), 1hw2_B(5.20e-03)
TACCGACCGNTNGGTNPubMed1hw2_AB(9.89e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --------RG--TGRGTG--RTET----HA--   L                           +--1h9t_B    
                                           +---------------------2 
  ------EGRG--TTRGTTTTRTET----HA--   L   +-5                     +--4p9u_F    
                                         ! ! 
  --------SGQG--YCNC--------------       ! +------------------------2ve9_C    
                                         ! 
  ------------------------YG------     --6                        +-2heo_D    
                                         !                 +------1 
  ----------------TTHT--KG--RC----   L   !         +-------3      +-7b0c_A    
                                         !         !       ! 
  RGRTKG--------------------------   L   +---------4       +--------6lui_A    
                                                   ! 
  --------TC--STKTPTTTFT--------RT                 +----------------4ass_H    
                                       

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updated Fri Sep 13 15:38:09 2024