| structure name | THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL (PROTEIN TRANSCRIPTION FACTOR MAX) |
| reference | Brownlie et al. Structure 5 509 1997 |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.80, R-factor=0.213) |
| structural superfamily | HLH, helix-loop-helix DNA-binding domain; |
| sequence family | Helixloophelix DNAbinding domain; |
| multimeric complexes | 1hlo_AB |
| reference complex | 5eyo_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | HNLERR |
Estimated binding specificities ?
| readout + contact |  |
A | 0 0 54 0 13 C | 96 96 13 96 16 G | 0 0 13 0 54 T | 0 0 16 0 13scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: MAX | ||
| CACGTG | PubMed | 1hlo_B(4.51e-04), 1hlo_AB(8.29e-10) |
| CATGTG | PubMed | 1hlo_AB(6.79e-05) |
| CANNTG | PubMed | 1hlo_AB(3.37e-03) |
| CACATG | PubMed | 1hlo_AB(6.79e-05) |
| AACGTT | PubMed | 1hlo_AB(3.37e-03) |
| CACGCG | PubMed | 1hlo_B(4.51e-04), 1hlo_AB(6.79e-05) |
| CAAGTG | PubMed | 1hlo_AB(6.79e-05) |
| GACCACGTGGTC | PubMed | 1hlo_B(1.83e-05), 1hlo_AB(1.35e-09) |
Dendrogram of similar interfaces ?
matrix formatKT----HGNT--ECRCRG L +-----------------------------1nkp_A ! ------HGNT--ECRCRG L ! +----------------7d8t_A +-6 +-------2 ------HGNTMTEARCRG ! ! +---4 +----------------1nlw_D ! ! ! ! --NTRGEC--RC------ ! ! ! +------------------------2ql2_A ! +-5 ------RTNT--ECRCRG L +-7 ! +------------------4h10_B ! ! +---------3 ------HGSTITETRCRG L ! ! ! +4h10_A ! ! +-----------------1 ------HG----ETRTRG --8 ! +5v0l_A ! ! ------HG----ETRCRG L ! +-----------------------------5gnj_I ! ----QG----VTECRCRG L +-----------------------------1an4_A |
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updated Thu Sep 12 14:43:20 2024