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structure nameMSX-1 HOMEODOMAIN/DNA COMPLEX STRUCTURE
(Homeotic protein Msx-1)
referenceAbate-Shen et al. Biochemistry 40 12013 2001
sourceMus musculus
experimentX-ray (resolution=2.20, R-factor=0.205)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRKIQNR

Estimated binding specificities ?

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# IC=5.371 IC/col=0.767 n_of_columns=7 specificity:   
A |  10   0  74  96  10  24   0
C |  64   0  10   0  12  24   0
G |  10   0   2   0  10  24  96
T |  12  96  10   0  64  24   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MSX-1
TTAATTGPubMed1ig7_A(5.68e-05)
TGTCACTAATTGAAGGPubMed1ig7_A(1.61e-05)
ACTAATTGGPubMed1ig7_A(5.86e-07)
ACTAATTGPubMed1ig7_A(1.65e-07)
TAATTGPubMed1ig7_A(6.99e-06)

Dendrogram of similar interfaces ?

matrix format
  
  RART----VTKGNA--KA--   L                               +2lkx_A    
                                                       +-1 
  --RA----IAQTNA------   L   +-------------------------3 +5ego_B    
                             !                         ! 
  --RT----NT--NAIARG--   L   !                         +-1b72_B    
                             ! 
  --RT--QTVAQTNA------   L   !                           +-8osb_E    
                             !                         +-2 
  --RT----IAQCNAMG----   L   !               +---------4 +-1b72_A    
                           --9               !         ! 
  --------NCRG--------   L   !   +-----------6         +---4xrm_B    
                             !   !           ! 
  --RC----IAQCNAYC----   L   !   !           !        +----3rkq_B    
                             ! +-7           +--------5 
  ----RT--NT--NAIARG--   L   ! ! !                    +----4cyc_B    
                             +-8 ! 
  --------VTCCNAQA--RT   L     ! +-------------------------8g87_X    
                               ! 
  --------------YCFAKC   L     +--------------------------6pe2_B    
                           

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updated Sat Jan 10 04:40:33 2026