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structure nameMSX-1 HOMEODOMAIN/DNA COMPLEX STRUCTURE
(Homeotic protein Msx-1)
referenceAbate-Shen et al. Biochemistry 40 12013 2001
sourceMus musculus
experimentX-ray (resolution=2.20, R-factor=0.205)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRKIQNR

Estimated binding specificities ?

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# IC=5.766 IC/col=0.824 n_of_columns=7 specificity:   
A |   0  24  54   0   0  96  13
C |  96  24  13   0   0   0  13
G |   0  24  16   0   0   0  54
T |   0  24  13  96  96   0  16
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MSX-1
TTAATTGPubMed1ig7_A(5.68e-05)
TGTCACTAATTGAAGGPubMed1ig7_A(1.61e-05)
ACTAATTGGPubMed1ig7_A(5.86e-07)
ACTAATTGPubMed1ig7_A(1.65e-07)
TAATTGPubMed1ig7_A(6.99e-06)

Dendrogram of similar interfaces ?

matrix format
  
  RART----VTKGNA--KA--   L           +-------------------2lkx_A    
                                     ! 
  --RT----IAQCNAMG----   L     +-----6              +----1b72_A    
                               !     !           +--4 
  --RC----IAQCNAYC----   L     !     !           !  +----3rkq_B    
                               !     +-----------5 
  --RT--QTVAQTNA------   L     !                 !    +--8osb_E    
                               !                 !    ! 
  --------NCRG--------   L   +-7                 +----3    +4xrm_B    
                             ! !                      !  +-1 
  --------NCITNARGRG--   L   ! !                      +--2 +6fqq_E    
                             ! !                         ! 
  ----RT--NT--NAIARG--   L --8 !                         +4cyc_B    
                             ! ! 
  --------VTCCNAQA--RT   L   ! +-------------------------8g87_X    
                             ! 
  --------------YCFAKC   L   +--------------------------6pe2_B    
                           

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updated Mon Jun 29 14:16:45 2026