1ig7_A : 3D-footprint complex

structure name	MSX-1 HOMEODOMAIN/DNA COMPLEX STRUCTURE (Homeotic protein Msx-1)
reference	Abate-Shen et al. Biochemistry 40 12013 2001
source	Mus musculus
experiment	X-ray (resolution=2.20, R-factor=0.205)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ig7_A interface=1,4,45,46,49,50,57, RkpRtpfttaqllalerkfrqkqylsiaeraefssslsltetqvKIwfQNrrakakRl
interface signature	RRKIQNR

Estimated binding specificities ?

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# IC=5.849 IC/col=0.836 n_of_columns=7

specificity:

A |   0  24  57   0   0  96  13
C |  96  24  13   0   0   0  13
G |   0  24  13   0   0   0  57
T |   0  24  13  96  96   0  13

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: MSX-1
TTAATTG	PubMed	1ig7_A(5.68e-05)
TGTCACTAATTGAAGG	PubMed	1ig7_A(1.61e-05)
ACTAATTGG	PubMed	1ig7_A(5.86e-07)
ACTAATTG	PubMed	1ig7_A(1.65e-07)
TAATTG	PubMed	1ig7_A(6.99e-06)

Dendrogram of similar interfaces ?

matrix format

  
  RART--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                           ! 
  --RT--IAQCNAMG----   L   !                        +----1b72_A    
                           !                +-------2 
  --RTQTVAQTNA------   L --6                !       !   +8osb_E    
                           !     +----------3       +---1 
  ------NCRG--------   L   !     !          !           +4xrm_B    
                           !   +-4          ! 
  --RC--IAQCNAYC----   L   !   ! !          +------------3rkq_B    
                           +---5 ! 
  ------VTCCNAQA--RT   L       ! +-----------------------8g87_X    
                               ! 
  ------------YCFAKC           +-------------------------6pe2_B

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updated Fri Sep 13 15:40:44 2024