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structure nameMSX-1 HOMEODOMAIN/DNA COMPLEX STRUCTURE
(Homeotic protein Msx-1)
referenceAbate-Shen et al. Biochemistry 40 12013 2001
sourceMus musculus
experimentX-ray (resolution=2.20, R-factor=0.205)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRKIQNR

Estimated binding specificities ?

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# IC=5.766 IC/col=0.824 n_of_columns=7 specificity:   
A |   0  24  54   0   0  96  16
C |  96  24  13   0   0   0  13
G |   0  24  13   0   0   0  54
T |   0  24  16  96  96   0  13
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MSX-1
TTAATTGPubMed1ig7_A(5.68e-05)
TGTCACTAATTGAAGGPubMed1ig7_A(1.61e-05)
ACTAATTGGPubMed1ig7_A(5.86e-07)
ACTAATTGPubMed1ig7_A(1.65e-07)
TAATTGPubMed1ig7_A(6.99e-06)

Dendrogram of similar interfaces ?

matrix format
  
  RART--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                           ! 
  --RTQTVAQTNA------   L   !                            +8osb_E    
                           !                          +-1 
  --RT--IAQCNAMG----   L   !                +---------2 +1b72_A    
                         --6                !         ! 
  ------NCRG--------   L   !     +----------3         +--4xrm_B    
                           !     !          ! 
  --RC--IAQCNAYC----   L   !   +-4          +------------3rkq_B    
                           !   ! ! 
  ------VTCCNAQA--RT   L   +---5 +-----------------------8g87_X    
                               ! 
  ------------YCFAKC   L       +-------------------------6pe2_B

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updated Sun Aug 3 05:37:15 2025