interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXO3A-DBD BOUND TO DNA
(FORKHEAD BOX PROTEIN O3A)
referenceHuang et al. 'Nucleic 35 6984 2007
sourceHOMO SAPIENS
experimentX-ray (resolution=2.70, R-factor=0.242)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSR

Estimated binding specificities ?

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# IC=3.907 IC/col=0.651 n_of_columns=6 specificity:   
A |   4  78  96  38   7  56
C |   2   6   0  19  75  13
G |   2   6   0  19   7  14
T |  88   6   0  20   7  13
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOXO3A
GTAAACAPubMed2uzk_A(6.32e-06)
TTGTTTCAPubMed2uzk_A(6.38e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----ST------NASTRTHT--ST----------   L                    +---3l2c_A    
                                                      +-----1 
  ------------NASTRGHT--STLT--------   L       +------2     +---7cby_C    
                                               !      ! 
  --------STRTSTHG------------RA----   L   +---3      +---------3zpl_B    
                                           !   ! 
  --LA--NTTTETYTRG------------------   L --4   +----------------1f4k_B    
                                           ! 
  TT------KATTQTTG--LTRT----KA--FTYT   L   +--------------------2p7c_B    
                                         

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updated Fri Sep 13 16:41:20 2024