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structure nameI-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY (-7C)
(Site-specific DNA endonuclease I-MsoI)
referenceStoddard et al. 'Nucleic 38 5601 2010
sourceMonomastix sp.
experimentX-ray (resolution=2.90, R-factor=0.252)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes1m5x_AB 2fld_AB 3ko2_AB 3ko2_FG 3mip_AB 3mis_AB
reference complex2fld_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSYRIRDEIRRDIW

Estimated binding specificities ?

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# IC=9.805 IC/col=1.089 n_of_columns=9 specificity:   
A |  57   0  96   0  96  13   0   0   0
C |  13   0   0  96   0  16   0   0  96
G |  13  96   0   0   0  54   0   0   0
T |  13   0   0   0   0  13  96  96   0
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updated Thu Jan 8 21:59:14 2026