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structure nameI-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY
(DNA ENDONUCLEASE I-MSOI)
referenceHavranek et al. Nature 441 656 2006
sourceMonomastix sp.
experimentX-ray (resolution=2.00, R-factor=0.229)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes1m5x_AB 2fld_AB 3ko2_AB 3ko2_FG 3mip_AB 3mis_AB
redundant complexes1m5x_A 3ko2_G 3mip_B 3mis_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSYLIRDYQINRRDIDR

Estimated binding specificities ?

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# IC=10.630 IC/col=1.063 n_of_columns=10 specificity:   
A |   9   0  96   0   0   9  67   0   0   0
C |  67   0   0  96  96   9   9  96   0   0
G |   9  96   0   0   0  11  11   0   0  96
T |  11   0   0   0   0  67   9   0  96   0
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Dendrogram of similar interfaces ?

matrix format



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updated Sun Aug  3 06:12:32 2025