interface graph thumbnail
legend  pdf

structure nameI-MSOI RE-DESIGNED FOR ALTERED DNA CLEAVAGE SPECIFICITY
(DNA ENDONUCLEASE I-MSOI)
referenceHavranek et al. Nature 441 656 2006
sourceMonomastix sp.
experimentX-ray (resolution=2.00, R-factor=0.229)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes1m5x_AB 2fld_AB 3ko2_AB 3ko2_FG 3mip_AB 3mis_AB
redundant complexes1m5x_A 3ko2_G 3mip_B 3mis_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSYLIRDYQINRRDIDR

Estimated binding specificities ?

readout + contactlogo
# IC=10.523 IC/col=1.052 n_of_columns=10 specificity:   
A |   0  96   0   8  69   0   0   9   0   8
C |  96   0   0   8   8   0   0   0  96  11
G |   0   0  96   8   8  96  96   0   0  69
T |   0   0   0  72  11   0   0  87   0   8
scan!

Dendrogram of similar interfaces ?

matrix format



home

updated Tue Dec 17 22:43:08 2024