4x0p_B : 3D-footprint complex

structure name	TERNARY COMPLEX OF HUMAN DNA POLYMERASE THETA C-TERMINAL DOMAIN BINDING DDATP OPPOSITE A TETRAHYDROFURAN AP SITE ANALOG (DNA polymerase theta)
reference	Doublie et al. Nat.Struct.Mol.Biol. 22 304 2015
source	Homo sapiens
experiment	X-ray (resolution=3.91, R-factor=0.244)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family A;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4x0p_B interface=300,304,336,346,433,523,574, slsiidvasdqnlfqtfikewrckkrfsislacekirddtlvvglavcwggrdayyfslldpsltlkdrmwylqsclrkesdkecsvviydfiqsykilllscgisleqsyedpkvacwlldpdsqeptlhsivtsflphelpllegmetsqgiqslglnagsehsgryrasvesilifnsmnqlnsllqkenlqdvfrkvempsqyclallelngigfstaecesqkhimqakldaietqayqlaghsfsftssddiaevlflelklppqfstskdvlnklkalhplpglilewrritNaitKvvfplqrekclnpflgmeriypvsqshtatgRitftepniqNvprdfeikmgmpfsismrhafvpfpggsilaadysqlelrilahlshdrrliqvlntgadvfrsiaaewkmiepesvgddlrqqakQicygiiygmgakslgeqmgikendaacyidsfksrytginqfmtetvknckrdgfvqtilgrrrylpgikdnnpyrkahaerqaintivQgsaadivkiatvniqkqletfhstfkshghregmlqsdcpirggffilqlHdellyevaeedvvqvaqivknemesavklsvklkvkvkigaswgelkdfdv
interface signature	NKRNQQH

Estimated binding specificities ?

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# IC=4.475 IC/col=0.746 n_of_columns=6

specificity:

A |   0   0  57  16  24   0
C |   0  96  13  13  24  96
G |   0   0  13  13  24   0
T |  96   0  13  54  24   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ------------------------NA--KG----------RC----NT--QC--------------------NG--YGATRT--QG--HC   L                                    +--4x0p_B    
                                                                                                                     +--------------2 
  ----------------------------KA----------------NT------------------------------------QG--HT   L                     !              +--6xbu_A    
                                                                                                               +-----3 
  --------------------------RC------------RA--NGNG----YG--YT--SCYC------------------NTQT----   L               !     !                 +6vdd_A    
                                                                                                             +-4     +-----------------1 
  --NGKGYGMG--RC--EG--------------SGHGVC----------------------------------------------------                 ! !                       +1kln_A    
                                                                                                           +-5 ! 
  ------------------------KT----YG--------RG--NGNG----YG--YAIGSCYC----NGRC--FG--------QA--HG               ! ! +-----------------------4yfu_D    
                                                                                                         +-6 ! 
  ------------------------KT--------------RG------EGKGYGACYCAC----RC----------QTATRTNGQG--HC   L         ! ! +-------------------------4xvk_A    
                                                                                                       +-7 ! 
  ------------------AAVAAAKC--------------RT--NGNC--TC----YCMCSAHARAQAEA------------NGQG----           ! ! +--------------------------6fbc_A    
                                                                                                     +-8 ! 
  ----------------------------------------RT--NGQG------------------------------------------         ! ! +---------------------------1x9m_A    
                                                                                                   +-9 ! 
  --------------------------------------------NANC----FC--YG------RG--------------RGNGQC----   L   ! ! +---------------------------1tau_A    
                                                                                                 -10 ! 
  LCNC--FC--RC--YA--------------------------------------------------------------------------       ! +-----------------------------4fzx_D    
                                                                                                   !  
  --------------------------------------RCRCYC----------TTYT----------------------------HT--   L   +-----------------------------1msw_D

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updated Fri Sep 13 18:57:02 2024