interface graph thumbnail
legend  pdf

structure namePOLYMERASE DOMAIN OF POLYMERASE-THETA
(DNA POLYMERASE THETA)
referencePomerantz et al. 'Sci 7 ? 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=3.29, R-factor=0.253)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family A;
reference complex8gd7_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKNQH

Estimated binding specificities ?

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# IC=2.714 IC/col=0.678 n_of_columns=4 specificity:   
A |  67   0   9   9
C |   9   0   9   9
G |  11   0   9  69
T |   9  96  69   9
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------------------KA----------------NT--------------------------------------------QG----HT   L                                  +-6xbu_A    
                                                                                                                        +-----------------2 
  ----------------------NA--KG----------RC----NT--QC----------------------------NG--YGATRT--QG----HC                    !                 +-4x0p_B    
                                                                                                                        ! 
  --------------------------RC----------RA--NGNG----YG--YT--SCYC--------------------------NTQT------   L                !                   +-6vdd_A    
                                                                                                                        !                 +-1 
  ------------------------KT--YG--------RG--NGNG----YG--YAIGSCYC----NG--RC--------FG--------QA----HG                    !              +--3 +-4yfu_D    
                                                                                                                +-------8              !  ! 
  NGKGYGMG--RC--EG--------------SGHGVC--------------------------------------------------------------            !       !           +--5  +-1kln_A    
                                                                                                                !       !           !  ! 
  ----------------AAVAAA--KC------------RT--NGNC--TC----YCMCSAHARAQAEA--------------------NGQG------            !       !           !  ! +--6fbc_A    
                                                                                                                !       !  +--------6  +-4 
  ------------------------------------------NANC----FC--YG------RG----------------------RGNGQC------   L      +-9       !  !        !    +--1tau_A    
                                                                                                              ! !       +--7        ! 
  ----------------------KT--------------RG------EGKGYGACYCAC----RC------------------QTATRTNGQG----HC   L      ! !          !        +-------4xvk_A    
                                                                                                              ! !          ! 
  --------------------------------------RT--NGQG--------YA------------------------------------QA----       +-10 !          +----------------1x9m_A    
                                                                                                           !  ! ! 
  ------------------------------------RCRCYC----------TTYT--------------------------------------HT--       !  ! +---------------------------1msw_D    
                                                                                                         -11  !  
  --------------------------------------------------------------------SGRGPTSGRG--------------------   L   !  +----------------------------7bhy_A    
                                                                                                           !  
  NC--FC--RC--YA------------------------------------------------------------------------------------       +-----------------------------4fzx_D    
                                                                                                         

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updated Fri Sep 13 03:12:30 2024