interface graph thumbnail
legend  pdf

structure namePOL DOMAIN OF POL1 FROM M. SMEGMATIS COMPLEX WITH DNA PRIMER-TEMPLATE AND DNTP
(DNA polymerase I)
referenceGoldgur et al. 'Nucleic 48 3165 2020
sourceMycolicibacterium smegmatis
experimentX-ray (resolution=1.90, R-factor=0.192)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family A;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRNNRYNQH

Estimated binding specificities ?

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# IC=1.417 IC/col=0.354 n_of_columns=4 specificity:   
A |  15   5  26  50
C |  60  13  14  40
G |  14  69  11   2
T |   7   9  45   4
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------------------RC----------RANGNGRT----YG--YT--SCYC--------------------------NTQT--   L                                +-6vdd_A    
                                                                                                                                +-1 
  ----------------------KT----YG------RGNGNGRC----YG--YAIGSCYC----NG--RC--------FG--------QAHG                                +-2 +-4yfu_D    
                                                                                                                              ! ! 
  LCNGKGYGMGRCEG----------------SGHGVC--------------------------------------------------------                         +------4 +-1kln_A    
                                                                                                                       !      ! 
  ----------------------NA--KG--------RC--NT----QC----------------------------NG--YGATRT--QGHC                         !      +---4x0p_B    
                                                                                                                +------7 
  --------------IAAAVAAAKC------------RTNGNC----TC----YCMCSAHARAQAEA--------------------NGQG--                  !      !        +--6fbc_A    
                                                                                                                !      ! +------3 
  --------------------------------------NANC------FC--YG------RG----------------------RGNGQC--   L              !      ! !      +--1tau_A    
                                                                                                     +----------8      +-6 
  ----------------------KT------------RG------EGKGYGACYCAC----RC------------------QTATRTNGQGHC   L   !          !        ! +-------4xvk_A    
                                                                                                     !          !        +-5 
  ------------------------KA--------------NT----------------------------------------------QGHT   L --9          !          +-------6xbu_A    
                                                                                                     !          ! 
  ----------------------------KT------RTNG------------YA----------------------------------QA--       !          +-----------------1x9m_A    
                                                                                                     ! 
  ------------------------------------------------------------------SGRGPTSGRG----------------   L   +----------------------------7bhy_A    
                                                                                                   

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updated Sat Sep 14 00:05:39 2024