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structure nameANCMR DNA BINDING DOMAIN - (+)GRE COMPLEX
(ANCMR DNA BINDING DOMAIN)
referenceOrtlund et al. Proc.Natl.Acad.Sci.USA 113 326 2016
sourceUNIDENTIFIED
experimentX-ray (resolution=2.20, R-factor=0.197)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2c7a_AB 4ond_AB 4ond_EF 4oor_AB 4oor_EF 4ov7_AB 4ov7_EF 5cbz_AB 5cbz_EF 5cc0_AB
redundant complexes2c7a_A 4ond_B 4oor_A 4ov7_A 5cc0_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |  13  24  54   0  96
C |  13  24  13  96   0
G |  57  24  13   0   0
T |  13  24  16   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --EAKG--RTRTRT                         +2han_B    
                                     +---1 
  --EAKG--RTRTRT                  +--4   +4umm_E    
                                  !  ! 
  --ECKG--KGRG--   L       +------5  +---2ff0_A    
                           !      ! 
  --ECKG--RGRG--   L     +-6      +------3dzy_D    
                         ! ! 
  ----KAVA--RA--   L     ! !             +5e69_A    
                       +-8 +-------------2 
  --ECKG--KGRG--       ! !               +3dzy_A    
                       ! ! 
  --ETKGAT--RG--   L --9 +---------------1lat_A    
                       ! 
  --DGKG--RTRG--   L   !                 +3cbb_A    
                       ! +---------------3 
  CAECKG--KGRG--   L   +-7               +6l6q_B    
                         ! 
  ----KGVT--RG--         +---------------5emp_A

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updated Fri Sep 13 19:23:52 2024