5ed4_A : 3D-footprint complex

structure name	STRUCTURE OF A PHOP-DNA COMPLEX (Response regulator)
reference	'Sci 6 24442 2016
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.40, R-factor=0.185)
structural superfamily	CheY-like;C-terminal effector domain of the bipartite response regulators;
sequence family	Response regulator receiver domain; Transcriptional regulatory protein, C te;
multimeric complexes	5ed4_AB 5ed4_EF
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5ed4_A interface=187,188,190,191,192,194,195,212, tpearvlvvddeanivellsvslkfqgfevytatngaqaldraretrpdavildvmmpgmdgfgvlrrlradgidapalfltardslqdkiagltlggddyvtkpfsleevvarlrvilrragvrltfadieldeethevwkagqpvslspteftllryfvinagtvlskpkildhvwrydfggdvNVvESYvSYlrrkidtgekrllhtlRgvgyvlrepr
interface signature	NVESYSYR

Estimated binding specificities ?

readout + contact

# IC=7.670 IC/col=0.959 n_of_columns=8

specificity:

A |   7   0  75   0  96   0   7   9
C |   9  96   7  96   0   0  75   7
G |   7   0   7   0   0  96   7   7
T |  73   0   7   0   0   0   7  73

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: PHOP
TCACAGC	PubMed	5ed4_A(1.29e-11), 5ed4_AB(1.68e-03), 5ed4_EF(1.93e-05)

Dendrogram of similar interfaces ?

matrix format

  
  ----RG--DTVTSTRG----WT----   L       +-----------------------------6lxn_A    
                                     +-1 
  ------------YG------------       +-2 +-----------------------------3eyi_B    
                                   ! ! 
  --TTKATTQTTG----LTRT--FTYT   L --3 +-----------------------------2p7c_B    
                                   ! 
  ET------------------------       +-----------------------------7aud_E

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updated Fri Sep 13 19:30:35 2024