interface graph thumbnail
legend  pdf

structure namePRDM9-ALLELE-C ZNF8-13
(PR domain zinc finger protein 9)
referencePatel et al. 'J. 292 15994 2017
sourceHomo sapiens
experimentX-ray (resolution=2.42, R-factor=0.176)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
reference complex5ei9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSHRRDSHDSNWSVRDSNSHR

Estimated binding specificities ?

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# IC=20.861 IC/col=1.043 n_of_columns=20 specificity:   
A |   0   0   0  24  84  96   0   0   0   0   7  96   9   0   0   0   0   0   7   3
C |   0   0   0  24   6   0  96   0  73   0  73   0  73   8   0   0   0   0  11  73
G |  96  96  96  24   3   0   0  96   3   0   7   0   7   0  96  96  96  96   7   9
T |   0   0   0  24   3   0   0   0  20  96   9   0   7  88   0   0   0   0  71  11
scan!

Dendrogram of similar interfaces ?

matrix format
  
  SGHGRGRGDC--SCHG----DCSANA----WC--SCVG--RGDCSGNA------STHGRG--   L                    +-----------5v3g_A    
                                                                                     +--2 
  --------------------ECSGKGRG--DG--YCKG--RGQA--TC----RASCDCVT--   L                 !  !   +-------5k5h_A    
                                                                            +--------3  +---1 
  ----------------------------NGKT--WTKG------HTHGRGTGTTACNAKGRG   L        !        !      +-------1tf3_A    
                                                                          +-4        ! 
  ------------------RGSTYGYC----QC--TGSTRGYT--------------------          ! !        +--------------4is1_C    
                                                                       +--5 ! 
  --------QA----TCRG--RGYCRT------------------------------------   L   !  ! +-----------------------7txc_E    
                                                                     --6  ! 
  --------------------NTSTNAVT--QTSTSGKG--RG--------------------   L   !  +------------------------6u9q_A    
                                                                       ! 
  ------QT--AG--KGRG--RGDCKG------------------------------------   L   +---------------------------7n5w_A    
                                                                     

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updated Thu Sep 12 22:07:50 2024