interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF MOUSE MUTYH IN COMPLEX WITH DNA CONTAINING AP SITE ANALOGUE:8-OXOG (FORM II)
(Adenine DNA glycosylase)
referenceNakabeppu et al. 'Nucleic 49 7154 2021
sourceMus musculus
experimentX-ray (resolution=1.97, R-factor=0.179)
structural superfamilyDNA-glycosylase;Nudix;
sequence familyHhHGPD superfamily base excision DNA r; NUDIX domain; Helixhairpinhelix motif; Ironsulfur binding domain of endonucle;
redundant complexes7ef8_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQQQTYSRRSH

Estimated binding specificities ?

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# IC=2.268 IC/col=0.567 n_of_columns=4 specificity:   
A |   0   9  10  16
C |  96   9  13  16
G |   0  67  63  48
T |   0  11  10  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------QG--QG----YC----------------RCSCHC   L                          +---7ef9_A    
                                                          +-----------------2 
  ----------QG--RG----YC------------------SCHC            !                 +---6u7t_A    
                                                       +--6 
  --------------------YG----------ACCTRG------         !  !            +--------5kn8_A    
                                                       !  +------------4 
  ----------QTLAHGAT------KT------------------       +-7               +--------3s6i_A    
                                                     ! ! 
  ----------QGCGTA----------------------------       ! !                +-------1orn_A    
                                                     ! !           +----3 
  ----------NG--RG------FGRC------------------     --8 +-----------5    +-------4ejy_A    
                                                     !             ! 
  --------AGNG------RCFC----RG--RA------------       !             +------------3knt_A    
                                                     ! 
  --------NGRGTG------LG--LCRG----------------       !                         +7kz0_A    
                                                     +-------------------------1 
  LTVTQTLTNGRGTG------LC--LCRGYT--------------                                 +4ofa_A    
                                                   

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updated Wed Dec 18 08:53:27 2024