7ef9_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF MOUSE MUTYH IN COMPLEX WITH DNA CONTAINING AP SITE ANALOGUE:8-OXOG (FORM II) (Adenine DNA glycosylase)
reference	Nakabeppu et al. 'Nucleic 49 7154 2021
source	Mus musculus
experiment	X-ray (resolution=1.97, R-factor=0.179)
structural superfamily	DNA-glycosylase;Nudix;
sequence family	HhHGPD superfamily base excision DNA r; NUDIX domain; Helixhairpinhelix motif; Ironsulfur binding domain of endonucle;
redundant complexes	7ef8_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7ef9_A interface=61,62,64,67,102,104,108,276,360,361, qasvspyhlfsdvadvtafrsnllswydqekrdlpwrnlakeeansdrrayavwvsevmlQQtQvaTvidyytrwmqkwpklqdlasasleevnqlwsglgYySrgrRlqegarkvveelgghmprtaetlqqllpgvgrytagaiasiafdqvtgvvdgnvlrvlcrvraigadptstlvshhlwnlaqqlvdparpgdfnqaamelgatvctpqrplcshcpvqslcrayqrvqrgqlseecalntrqcqlcltssspwdpsmgvanfprkasRrppreeysatcvveqpgaiggplvllvqrpdsgllaglwefpsvtlepseqhqhkallqelqrwcgplpairlqhlgevihifSHikltyqvyslaldqapastappgarwltweefcnaavstamkkvfrmyedhrq
interface signature	QQQTYSRRSH

Estimated binding specificities ?

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# IC=2.268 IC/col=0.567 n_of_columns=4

specificity:

A |   0   9  10  16
C |  96   9  13  16
G |   0  67  63  48
T |   0  11  10  16

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Dendrogram of similar interfaces ?

matrix format

  
  ----------QG--QG----YC----------------RCSCHC   L                          +---7ef9_A    
                                                          +-----------------2 
  ----------QG--RG----YC------------------SCHC            !                 +---6u7t_A    
                                                       +--6 
  --------------------YG----------ACCTRG------         !  !            +--------5kn8_A    
                                                       !  +------------4 
  ----------QTLAHGAT------KT------------------       +-7               +--------3s6i_A    
                                                     ! ! 
  ----------QGCGTA----------------------------       ! !                +-------1orn_A    
                                                     ! !           +----3 
  ----------NG--RG------FGRC------------------     --8 +-----------5    +-------4ejy_A    
                                                     !             ! 
  --------AGNG------RCFC----RG--RA------------       !             +------------3knt_A    
                                                     ! 
  --------NGRGTG------LG--LCRG----------------       !                         +7kz0_A    
                                                     +-------------------------1 
  LTVTQTLTNGRGTG------LC--LCRGYT--------------                                 +4ofa_A

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updated Sun Aug 3 16:17:47 2025