interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF CDX1 BOUND TO HYDROXYMETHYLATED DNA
(Homeobox protein CDX-1)
referenceMorgunova et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.78, R-factor=0.220)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes5lux_K
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRKIQN

Estimated binding specificities ?

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# IC=7.024 IC/col=0.878 n_of_columns=8 specificity:   
A |  15  10   5  55   0  96  96  96
C |  50   5   5  16   0   0   0   0
G |  16  71   5  15   0   0   0   0
T |  15  10  81  10  96   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RARA----IAQTNA------   L                               +-5ego_B    
                                 +-----------------------2 
  --RT----NT--NAIARG--   L       !                       +-1b72_B    
                                 ! 
  --RT--QTVAQTNA------   L       !                         +8osb_E    
                                 !                     +---1 
  --RT----VTKGNA--KA--   L     +-7            +--------3   +2lkx_A    
                               ! !            !        ! 
  ----RT--NT--NAIARG--   L     ! !     +------5        +---4cyc_B    
                               ! !     !      ! 
  --RT----IAQCNAMG----   L     ! !     !      !       +----1b72_A    
                             +-8 +-----6      +-------4 
  --RC----IAQCNAYC----   L   ! !       !              +----3rkq_B    
                             ! !       ! 
  --------NCICRG------   L --9 !       +-------------------4xrm_B    
                             ! ! 
  --------VTCCNAQA--RT   L   ! +---------------------------8g87_X    
                             ! 
  --------------YCFAKC   L   +---------------------------6pe2_B    
                           

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updated Sat Jan 10 17:13:09 2026