interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF CDX1 BOUND TO HYDROXYMETHYLATED DNA
(Homeobox protein CDX-1)
referenceMorgunova et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.78, R-factor=0.220)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes5lux_K
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRKIQN

Estimated binding specificities ?

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# IC=6.993 IC/col=0.874 n_of_columns=8 specificity:   
A |  15   5   6  55   0  96  96  96
C |  50  10   5  15   0   0   0   0
G |  16  71   5  15   0   0   0   0
T |  15  10  80  11  96   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--VTKGNA--KA--   L     +-----------------------------2lkx_A    
                           ! 
  RTQTVAQTNA------   L     !                            +8osb_E    
                           !             +--------------1 
  RT--IAQCNAMG----   L   +-5        +----2              +1b72_A    
                         ! !        !    ! 
  ----NCICRG------   L   ! !     +--3    +---------------4xrm_B    
                         ! !     !  ! 
  RC--IAQCNAYC----   L --6 +-----4  +--------------------3rkq_B    
                         !       ! 
  ----VTCCNAQA--RT   L   !       +-----------------------8g87_X    
                         ! 
  ----------YCFAKC   L   +-----------------------------6pe2_B    
                       

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updated Wed Dec 18 11:03:52 2024