interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF CDX1 BOUND TO HYDROXYMETHYLATED DNA
(Homeobox protein CDX-1)
referenceMorgunova et al. 'To ? ? ?
sourceHomo sapiens
experimentX-ray (resolution=2.78, R-factor=0.220)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes5lux_K
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRKIQN

Estimated binding specificities ?

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# IC=6.417 IC/col=0.802 n_of_columns=8 specificity:   
A |   0   0   0  96  17   0  24  17
C |   0   0   0   0  10   8  24  43
G |   0   0   0   0  17  80  24  17
T |  96  96  96   0  52   8  24  19
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                         ! 
  RTQTVAQTNA------   L   !                            +8osb_E    
                         !                          +-1 
  RT--IAQCNAMG----   L   !                +---------2 +1b72_A    
                       --6                !         ! 
  ----NCICRG------   L   !     +----------3         +--4xrm_B    
                         !     !          ! 
  RC--IAQCNAYC----   L   !   +-4          +------------3rkq_B    
                         !   ! ! 
  ----VTCCNAQA--RT   L   +---5 +-----------------------8g87_X    
                             ! 
  ----------YCFAKC           +-------------------------6pe2_B    
                       

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updated Sat Sep 14 04:26:40 2024