interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE XENOPUS FOXH1 BOUND TO THE TGTGGATT SITE
(Forkhead box protein H1)
referenceMacias et al. 'To ? ? 2022
sourceXenopus laevis
experimentX-ray (resolution=2.82, R-factor=0.202)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRDSRHSK

Estimated binding specificities ?

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# IC=3.942 IC/col=0.438 n_of_columns=9 specificity:   
A |   0  12  12   2  13  60  25  19  13
C |   0  12  12   1  13  12  22  19  14
G |   0  60  12  92  56  12  22  19  56
T |  96  12  60   1  14  12  27  39  13
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------NASTRGHT--STLT--------   L                     +------7cby_C    
                                                        +--1 
  ----------NASTRTHT--ST----------   L           +------2  +------3l2c_A    
                                                 !      ! 
  ------STRTSTHG------------RA----   L   +-------3      +---------3zpl_B    
                                         !       ! 
  RT--LATTETYTRG------------------   L --4       +----------------1f4k_B    
                                         ! 
  --TT--KATTQTTG--LTRT----KA--FTYT   L   +------------------------2p7c_B    
                                       

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updated Sat Sep 14 07:52:38 2024