interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE XENOPUS FOXH1 BOUND TO THE TGTGGATT SITE
(Forkhead box protein H1)
referenceMacias et al. 'To ? ? 2022
sourceXenopus laevis
experimentX-ray (resolution=2.82, R-factor=0.202)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRDSRHSK

Estimated binding specificities ?

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# IC=3.976 IC/col=0.442 n_of_columns=9 specificity:   
A |  13  38  27  12  13   1  60  12  96
C |  56  19  22  12  56  93  12  60   0
G |  14  19  22  12  13   1  12  12   0
T |  13  20  25  60  14   1  12  12   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------NASTRGHT--STLT--------   L                     +------7cby_C    
                                               +-----------1 
  ----------NASTRTHT--ST----------   L     +---2           +------3l2c_A    
                                           !   ! 
  RT--LATTETYTRG------------------   L   +-3   +------------------1f4k_B    
                                         ! ! 
  ------STRTSTHG------------RA----   L --4 +----------------------3zpl_B    
                                         ! 
  --TT--KATTQTTG--LTRT----KA--FTYT   L   +------------------------2p7c_B    
                                       

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updated Wed Dec 18 14:50:59 2024