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legend  pdf

structure nameCRYSTAL STRUCTURE OF GSX2 HOMEODOMAIN IN COMPLEX WITH DNA
(GS homeobox 2)
referenceKovall et al. 'To ? ? ?
sourceMus musculus
experimentX-ray (resolution=2.21, R-factor=0.225)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRIQN

Estimated binding specificities ?

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# IC=5.181 IC/col=0.740 n_of_columns=7 specificity:   
A |   0   0  78  96   8  24  69
C |  10   0  10   0   8  24   8
G |   8   0   0   0   8  24  11
T |  78  96   8   0  72  24   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--IAQCNAMG----   L     +-----------------------------1b72_A    
                           ! 
  RTQTVAQTNA------   L     !                             +8osb_E    
                           !             +---------------1 
  RT--VTKGNA--KA--   L   +-5        +----2               +2lkx_A    
                         ! !        !    ! 
  ----NCICNARGRG--   L   ! !     +--3    +---------------4xrm_B    
                         ! !     !  ! 
  RC--IAQCNAYC----   L --6 +-----4  +--------------------3rkq_B    
                         !       ! 
  ----VTCCNAQA--RT   L   !       +-----------------------8g87_X    
                         ! 
  ----------YCFAKC   L   +-----------------------------6pe2_B    
                       

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updated Wed Dec 18 17:01:10 2024