interface graph thumbnail
legend  pdf

structure nameDIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL AND DTXR CONSENSUS BINDING SEQUENCE
(DIPHTHERIA TOXIN REPRESSOR)
referenceMurphy et al. Biochemistry 39 10397 2000
sourceCorynebacterium diphtheriae
experimentX-ray (resolution=3.00, R-factor=0.245)
structural superfamily"Winged helix" DNA-binding domain;Iron-dependent repressor protein, dimerization domain;
sequence familyIron dependent repressor, Nterminal D; Iron dependent repressor, metal bindin; MarR family;
multimeric complexes1f5t_ABCD
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSPTQR

Estimated binding specificities ?

contactlogo
# IC=2.635 IC/col=0.659 n_of_columns=4 specificity:   
A |  11   0   9   9
C |   9   0  67   9
G |  67  96   9  11
T |   9   0  11  67
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: DTXR
TTAGGTGAGACGCACCCATPubMed1f5t_ABCD(1.22e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----RGSTRTSTHG------------   L                                     +3zpl_B    
                                       +-----------------------------1 
  --DCLT--AGTTRG--RG--------   L     +-2                             +5h3r_A    
                                     ! ! 
  TT----KATTQTTGLTRTKA--FTYT   L   +-3 +-----------------------------2p7c_B    
                                   ! ! 
  --SG--PTPGTT--------HG----   L --4 +-----------------------------7d98_Q    
                                   ! 
  --------------YG----------       +-----------------------------3eyi_B    
                                 

home
updated Fri Sep 13 15:35:45 2024