interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HOXA9 AND PBX1 HOMEODOMAINS BOUND TO DNA
(HOMEOBOX PROTEIN HOX-A9)
referenceLaronde-Leblanc et al. 'Genes 17 2060 2003
sourceMUS MUSCULUS
experimentX-ray (resolution=1.90, R-factor=0.233)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes1puf_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQNM

Estimated binding specificities ?

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# IC=5.182 IC/col=0.740 n_of_columns=7 specificity:   
A |   9  11  24   0   0  96  67
C |   9   9  24   0   0   0   9
G |  59   9  24  96   0   0  11
T |  19  67  24   0  96   0   9
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RART--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                           ! 
  --RT--IAQCNAMG----   L   !                        +----1b72_A    
                         --5                +-------2 
  --RTQTVAQTNA------   L   !                !       !   +8osb_E    
                           !     +----------3       +---1 
  ------NCICNARGRG--   L   !     !          !           +4xrm_B    
                           +-----4          ! 
  --RC--IAQCNAYC----   L         !          +------------3rkq_B    
                                 ! 
  ------VTCCNAQA--RT   L         +-----------------------8g87_X    
                         

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updated Fri Sep 13 15:56:00 2024