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legend  pdf

structure nameCRYSTAL STRUCTURE OF HNF-6ALPHA DNA-BINDING DOMAIN IN COMPLEX WITH THE TTR PROMOTER
(Hepatocyte nuclear factor 6)
referenceNishihira et al. Structure 15 75 2007
sourceRattus norvegicus
experimentX-ray (resolution=2.00, R-factor=0.247)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyCUT domain; Homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSQTSDRNMNRR

Estimated binding specificities ?

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# IC=8.850 IC/col=1.106 n_of_columns=8 specificity:   
A |  76   0   0   0  96  38   0  96
C |   1   0   0  96   0  20   0   0
G |  19  96   0   0   0  19   0   0
T |   0   0  96   0   0  19  96   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-6ALPHA
CCAATPubMed2d5v_B(3.07e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----------RT--QTVAQTNA----   L                              +8osb_E    
                                                           +--1 
  ----------RA----IAQTNA----   L                      +----4  +5ego_B    
                                                      !    ! 
  ----------RT----IAQCNAMG--   L                +-----5    +--1b72_A    
                                                !     ! 
  ----------RT----VTKGNA--KA   L                !     !      +2lkx_A    
                                             +--6     +------3 
  ----------RT----NT--NAIARG   L             !  !            +1b72_B    
                                             !  ! 
  ----------RC----IAQCNAYC--   L   +---------7  +-------------3rkq_B    
                                   !         ! 
  ----------------NCICNARGRG   L   !         !                +4xrm_B    
                                 --8         +----------------2 
  ------------RT--NT--NAIARG   L   !                          +4cyc_B    
                                   ! 
  SGQATGCARG----------------   L   +--------------------------8g87_X    
                                 

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updated Sat Jan 10 05:10:50 2026