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legend  pdf

structure nameCRYSTAL STRUCTURE OF HNF-6ALPHA DNA-BINDING DOMAIN IN COMPLEX WITH THE TTR PROMOTER
(Hepatocyte nuclear factor 6)
referenceNishihira et al. Structure 15 75 2007
sourceRattus norvegicus
experimentX-ray (resolution=2.00, R-factor=0.247)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyCUT domain; Homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSQTSDRNMNRR

Estimated binding specificities ?

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# IC=7.300 IC/col=0.912 n_of_columns=8 specificity:   
A |   0  78  16   0   0  96   6  10
C |   0   6  14   0   0   0  78  10
G |   0   6  14   0  96   0   6  10
T |  96   6  52  96   0   0   6  66
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-6ALPHA
CCAATPubMed2d5v_B(3.07e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----------RTQTVAQTNA----   L                            +8osb_E    
                                           +--------------1 
  ----------RT--VTKGNA--KA   L        +----2              +2lkx_A    
                                      !    ! 
  ----------RT--IAQCNAMG--   L     +--3    +--------------1b72_A    
                                   !  ! 
  --------------NCICNARGRG   L   +-4  +-------------------4xrm_B    
                                 ! ! 
  ----------RC--IAQCNAYC--   L --5 +----------------------3rkq_B    
                                 ! 
  SGQATGCARG--------------   L   +------------------------8g87_X    
                               

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updated Tue Dec 17 22:39:47 2024