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legend  pdf

structure nameCRYSTAL STRUCTURE OF HNF-6ALPHA DNA-BINDING DOMAIN IN COMPLEX WITH THE TTR PROMOTER
(Hepatocyte nuclear factor 6)
referenceNishihira et al. Structure 15 75 2007
sourceRattus norvegicus
experimentX-ray (resolution=2.00, R-factor=0.247)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyCUT domain; Homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSQTSDRNMNRR

Estimated binding specificities ?

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# IC=9.267 IC/col=1.030 n_of_columns=9 specificity:   
A |   9  21   0   0   0  96  59   0  96
C |   2   9   0   0  96   0  19   0   0
G |   9  57  96   0   0   0   9   0   0
T |  76   9   0  96   0   0   9  96   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-6ALPHA
CCAATPubMed2d5v_B(3.07e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----------RTQTVAQTNA----   L                            +8osb_E    
                                                        +-1 
  ----------RT--VTKGNA--KA   L                +---------2 +2lkx_A    
                                              !         ! 
  ----------RT--IAQCNAMG--   L           +----3         +-1b72_A    
                                         !    ! 
  --------------NCICNARGRG   L   +-------4    +-----------4xrm_B    
                                 !       ! 
  ----------RC--IAQCNAYC--   L --5       +----------------3rkq_B    
                                 ! 
  SGQATGCARG--------------   L   +------------------------8g87_X    
                               

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updated Fri Sep 13 16:14:14 2024