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legend  pdf

structure nameCRYSTAL STRUCTURE OF HNF-6ALPHA DNA-BINDING DOMAIN IN COMPLEX WITH THE TTR PROMOTER
(Hepatocyte nuclear factor 6)
referenceNishihira et al. Structure 15 75 2007
sourceRattus norvegicus
experimentX-ray (resolution=2.00, R-factor=0.247)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyCUT domain; Homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSQTSDRNMNRR

Estimated binding specificities ?

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# IC=7.300 IC/col=0.912 n_of_columns=8 specificity:   
A |   0  78  16   0   0  96   6  10
C |   0   6  14   0   0   0  78  10
G |   0   6  14   0  96   0   6  10
T |  96   6  52  96   0   0   6  66
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-6ALPHA
CCAATPubMed2d5v_B(3.07e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----------RT--QTVAQTNA----   L                              +8osb_E    
                                                           +--1 
  ----------RT----VTKGNA--KA   L                    +------4  +2lkx_A    
                                                    !      ! 
  ----------RT----IAQCNAMG--   L                    !      +--1b72_A    
                                            +-------5 
  ----------------NCICNARGRG   L            !       !          +4xrm_B    
                                            !       !        +-2 
  ----------------NCITNARGRG   L   +--------6       +--------3 +6fqq_E    
                                   !        !                ! 
  ------------RT--NT--NAIARG   L   !        !                +4cyc_B    
                                 --7        ! 
  ----------RC----IAQCNAYC--   L   !        +-----------------3rkq_B    
                                   ! 
  SGQATGCARG----------------   L   +--------------------------8g87_X    
                                 

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updated Mon Jun 29 14:59:36 2026