interface graph thumbnail
legend  pdf

structure nameLEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES
(PROTEIN LYMPHOID ENHANCER-BINDING FACTOR)
sourceMUS MUSCULUS
experimentNMR
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKNMMESANYKRKK

Estimated binding specificities ?

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# IC=4.540 IC/col=0.567 n_of_columns=8 specificity:   
A |  12   0  15   2   3  82  39  11
C |  60   3  10  20   3   5  22  11
G |  12   2  15   3  87   3  10  65
T |  12  91  56  71   3   6  25   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: LEF1
GTTTGATPubMed2lef_A(1.69e-04)

Dendrogram of similar interfaces ?

matrix format
  
  RTNGFTIA--RA--NASGST--YAPG   L             +-----------------------1j46_A    
                                             ! 
  RCNTFTMA--RAHGNT--SA--YA--   L             !                       +3f27_D    
                                       +-----4               +-------1 
  RCNAFTIA--RG--NC--SALTYA--   L       !     !  +------------2       +2gzk_A    
                                       !     !  !            ! 
  RGNTFTMA--RT--NGRTSA--WANT   L     +-5     +--3            +-------7m5w_A    
                                     ! !        ! 
  RCNTFTMA--RAHGNAACST------   L     ! !        +--------------------4euw_A    
                                   +-6 ! 
  RCNGFTMA--RTHTNG--ST--YA--   L   ! ! +-----------------------------6t90_L    
                                 --7 ! 
  --STYGLCSGLAKTTGTCIG------       ! +-----------------------------7lbx_A    
                                   ! 
  KASTYGLASGLA--TGTCIT------   L   +-----------------------------3tmm_A    
                                 

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updated Fri Sep 13 16:29:04 2024