2lef_A : 3D-footprint complex

structure name	LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES (PROTEIN LYMPHOID ENHANCER-BINDING FACTOR)
source	MUS MUSCULUS
experiment	NMR
structural superfamily	HMG-box;
sequence family	HMG high mobility group box;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2lef_A interface=5,8,11,14,29,30,31,34,76,81,82,83,86, mhikKplNafMlyMkemranvvaestlkESAaiNqilgrrwhalsreeqakyyelarkerqlhmqlypgwsardnYgkkkKRKreK
interface signature	KNMMESANYKRKK

Estimated binding specificities ?

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# IC=8.636 IC/col=1.079 n_of_columns=8

specificity:

A |   0  16   0   0  96  64  96   0
C |  96  16   0  96   0  16   0   0
G |   0  16   0   0   0   0   0  96
T |   0  48  96   0   0  16   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: LEF1
GTTTGAT	PubMed	2lef_A(1.69e-04)

Dendrogram of similar interfaces ?

matrix format

  
  RTNGFTIA--RA--NASGST--YAPG   L             +-----------------------1j46_A    
                                             ! 
  RCNTFTMA--RAHGNT--SA--YA--   L             !                       +3f27_D    
                                       +-----4               +-------1 
  RCNAFTIA--RG--NC--SALTYA--   L       !     !  +------------2       +2gzk_A    
                                       !     !  !            ! 
  RGNTFTMA--RT--NGRTSA--WANT   L     +-5     +--3            +-------7m5w_A    
                                     ! !        ! 
  RCNTFTMA--RAHGNAACST------   L     ! !        +--------------------4euw_A    
                                   +-6 ! 
  RCNGFTMA--RTHTNG--ST--YA--   L   ! ! +-----------------------------6t90_L    
                                 --7 ! 
  --STYGLCSGLAKTTGTCIG------       ! +-----------------------------7lbx_A    
                                   ! 
  KASTYGLASGLA--TGTCIT------   L   +-----------------------------3tmm_A

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updated Sat Jan 10 05:23:31 2026