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legend  pdf

structure nameRETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
(PROTEIN THYROID HORMONE RECEPTOR)
referenceRastinejad et al. Nature 375 203 1995
sourceHOMO SAPIENS
experimentX-ray (resolution=1.90, R-factor=0.206)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2nll_AB 3m9e_AB 3m9e_EF
redundant complexes3m9e_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRRK

Estimated binding specificities ?

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# IC=2.933 IC/col=0.587 n_of_columns=5 specificity:   
A |  19  11  68   0   5
C |  20   8  11  95  78
G |  19  68  10   0   5
T |  38   9   7   1   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  CAECKG--KGRGRT   L                          +----1cit_A    
                                +-------------3 
  --EAKG--KTRG--   L            !             !    +4umm_A    
                                !             +----1 
  ----KGVG--RG--   L            !                  +4tnt_B    
                         +------5 
  ----KGVT--RG--   L     !      !                  +5emc_A    
                         !      !  +---------------2 
  --ECKGAGKGRG--   L   +-6      +--4               +1hcq_E    
                       ! !         ! 
  --ECKGAGKTRG--   L   ! !         +---------------4aa6_B    
                     --7 ! 
  ----KGVT--RG--   L   ! +-------------------------2c7a_B    
                       ! 
  --ECKGAG--RG--   L   +--------------------------4ond_A    
                     

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updated Mon Jun 29 15:24:29 2026