interface graph thumbnail
legend  pdf

structure nameRETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
(PROTEIN THYROID HORMONE RECEPTOR)
referenceRastinejad et al. Nature 375 203 1995
sourceHOMO SAPIENS
experimentX-ray (resolution=1.90, R-factor=0.206)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2nll_AB 3m9e_AB 3m9e_EF
redundant complexes3m9e_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRRK

Estimated binding specificities ?

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# IC=2.933 IC/col=0.587 n_of_columns=5 specificity:   
A |  19  11  68   0   5
C |  20   8  11  95  78
G |  19  68  10   0   5
T |  38   9   7   1   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  CAECKG--KGRGRT   L                             +---1cit_A    
                                   +-------------1 
  --EAKG--KTRG--   L           +---2             +---4umm_A    
                               !   ! 
  ----KGVT--RG--   L         +-3   +-----------------2c7a_B    
                             ! ! 
  --ECKGAG--RG--   L   +-----4 +---------------------4ond_A    
                       !     ! 
  --ECKGAGKTRG--   L --5     +-----------------------4aa6_B    
                       ! 
  --ECKGAGKGRG--   L   +-----------------------------1hcq_E

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updated Sat Jan 10 05:25:27 2026