interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF A HETERODIMER OF CDC6/ORC1 INITIATORS BOUND TO ORIGIN DNA (FROM S. SOLFATARICUS)
(CELL DIVISION CONTROL PROTEIN 6 HOMOLOG 3)
referenceCunningham Dueber et al. Science 317 1210 2007
sourceSULFOLOBUS SOLFATARICUS
experimentX-ray (resolution=3.35, R-factor=0.226)
structural superfamilyP-loop containing nucleoside triphosphate hydrolases;
sequence familyCDC6, C terminal;
multimeric complexes2qby_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSRNRV

Estimated binding specificities ?

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# IC=1.722 IC/col=0.215 n_of_columns=8 specificity:   
A |   5  15  24  29  21   6  24   6
C |  77  53  25  20  33   8  23  14
G |   9  15  22  25  21  72  22  21
T |   5  13  25  22  21  10  27  55
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------------------ST--RG----------------NGRA----VG----   L                                         +--2qby_B    
                                                                                    +----------------1 
  --TG--------------TT--RGRT--------------SGRT--KT------   L                        !                +--2v1u_A    
                                                                                +---3 
  ------SA----------------------------------------------   L                    !   !       +-----------2qby_A    
                                                                             +--5   +-------2 
  ----------RA------------------------------------------                     !  !           +-----------7jgs_A    
                                                                           +-6  ! 
  TTRA--------------------------------------------------                   ! !  +-----------------------7jps_B    
                                                                         +-7 ! 
  ----------------TT----KATTQTTGLTRT----KA----------FTYT   L             ! ! +--------------------------2p7c_B    
                                                                         ! ! 
  ------------------NT--TCTA----------------------RT----   L           +-8 +----------------------------5zux_A    
                                                                       ! ! 
  ----KA------------------------------------------------               ! !    +-----------------------3r8f_C    
                                                                     +-9 +----4 
  --------NT--------------------------------------------             ! !      +-----------------------5vvr_M    
                                                                  +-10 ! 
  --------------LT--NTHGTA--YTRG--------------KGQA------          !  ! +-----------------------------2efw_A    
                                                               +-11  !  
  ------------------------------HT--ST------------------   L   !  !  +-----------------------------6akp_C    
                                                             -12  !  
  ------------IA----------------------------------------       !  +-----------------------------6ro4_B    
                                                               !  
  --------------------------RTVAITNA--MCRG--------------   L   +-----------------------------1akh_A    
                                                             

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updated Fri Sep 13 16:38:25 2024