| structure name | MOLECULAR BASIS OF HUMAN XPC GENE RECOGNITION AND CLEAVAGE BY ENGINEERED HOMING ENDONUCLEASE HETERODIMERS (DNA ENDONUCLEASE I-CREI) |
| reference | Cabaniols et al. Nature 456 107 2008 |
| source | CHLAMYDOMONAS REINHARDTII |
| experiment | X-ray (resolution=1.80, R-factor=0.153) |
| structural superfamily | Homing endonucleases; |
| sequence family | LAGLIDADG endonuclease; |
| multimeric complexes | 2vbj_AB 2vbo_AB 2xe0_AB 3mxb_AB 3mxb_RS 6fb0_AB 6fb5_AB |
| redundant complexes | 2vbj_B
 3mx9_A
3mxb_B
2xe0
6fb0
6fb5
|
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | SIQKSRQTYRSSVNIKT |
Estimated binding specificities ?
| readout + contact |  |
A | 54 96 96 96 0 24 0 54 C | 13 0 0 0 0 24 96 13 G | 16 0 0 0 96 24 0 13 T | 13 0 0 0 0 24 0 16scan! |
Dendrogram of similar interfaces ?
matrix formatSAIAQAKG----ST--RG------QATAYCRT--ST----VA--IT------KTTT-- L +2vbo_A +-1 SGIGQAEC----STYARG--KG--KGTA--RT--EC----VG----------KTTG-- L +-2 +2vbl_A ! ! SGIGQAKGNC--SC--RG--QG--DGTAYCAT--SC----VCKGRG--------TT-- L +-3 +6fb0_A ! ! SAIAQA------SC--RG--KG--QATAYC----ST----VA----------KTTT-- L +-4 +2vbl_B ! ! STITQAKGRG--STNTQG--ST--ATTC--YT--SC----VCDTRG--ST--KGTG-- L +-5 +2xe0_B ! ! SAIAQGKTNT--SCYAQA------QATCYARG--RG--SAVA----------KGTC-- L +-----7 +1t9i_B ! ! STITQAKGRG--STNTQT--ST--ATTC--YT--SC----VCDTRG--ST--KGTG-- L +-14 +3mxb_B ! ! SANCSCKGLT----------DAECNATG--RC----------------DAQA----QC L ! +-----2ex5_A +-15 SGIGQAKG----SC--KG------KGTA--YC--ST----VG--YA------KCTG-- L ! ! +6fb0_B ! ! +-6 STITQANG----ST--RG--RG--YCTCYCRG--------VCQT--------KGTC-- L ! +----11 +3mxb_R ! ! SAYCLCITRGDCYA--QG--------IG----RG--DT--IC--RG------------ L ! +2fld_B +------------16 CCMT--ACST--AT--QA--YA--ICTART----KGRT--VAEC--QT---------- L ! ! +4yit_A ! ! +-9 ST--NAVTHG--TCNAAT--LCYCECAT--NA--SADC--TCKTKG--SA-------- L ! ! ! +4lq0_A ! ! +-12 STMG--------KGYCRT----RGVTSA----MC------STQTRG--EC-------- L ! ! ! ! +5esp_A -17 ! ! +-10 --MGTASG------RAST--RGRGRG--------------DTRGRC--EC-------- L ! +-------13 +6bce_A ! ! STIGRGRG------MCLT--EC--STKG--TTNA--------MGRT--SC-------- L ! ! +5t2n_A ! +-8 SA--RGRGNT--KTSTST--EC--QGTA----ST------AT--KG------------ L ! +6bd0_A ! --YT------------RGSGECRGVTTGQGVG--------RTEARG--SC-------- L +----------------------2vs7_A |
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updated Sat Jan 10 05:35:58 2026