interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE COMPLEX COMPRISED OF ETS1(G333P), RUNX1, CBFBETA, AND THE TCRALPHA GENE ENHANCER DNA
referenceShiina et al. J.Mol.Biol. 427 1655 2015
experimentX-ray (resolution=2.70, R-factor=0.227)
structural superfamilyp53-like transcription factors;
sequence familyRunt domain;
multimeric complexes3wts_AC 3wtt_AC 3wtu_AC 3wtv_AC 3wtw_AC 3wtx_AC 3wty_AC 3wu1_AB 4l0y_AB 4l0z_AB 4l18_AB 4l18_EF
reference complex4l18_E
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVDRR

Estimated binding specificities ?

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# IC=5.495 IC/col=0.916 n_of_columns=6 specificity:   
A |  10   0  10   0   0  10
C |  12   0   0   0   0  66
G |  10  96  10  96  96  10
T |  64   0  76   0   0  10
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updated Thu Jan 8 23:38:07 2026