4l18_E : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF RUNX1 AND ETS1 BOUND TO TCR ALPHA PROMOTER (CRYSTAL FORM 3) (RUNT-RELATED TRANSCRIPTION FACTOR 1)
reference	Leukemia 28 2040 2014
source	MUS MUSCULUS
experiment	X-ray (resolution=2.30, R-factor=0.231)
structural superfamily	p53-like transcription factors;
sequence family	Runt domain;
multimeric complexes	3wu1_AB 4l18_AB 4l18_EF
redundant complexes	1h9d_C 3wu1
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4l18_E interface=29,91,119,120,123,126, vevladhpgelvrtdspnflcsvlpthwRcnktlpiafkvvalgdvpdgtlvtvmagndenysaelrnataamknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikitVDgpRepRgslsfserlseleql
interface signature	RRVDRR

Estimated binding specificities ?

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# IC=7.412 IC/col=0.927 n_of_columns=8

specificity:

A |   6   0   6   0   0   6   6   6
C |   6   0   6   0   0  78   6   6
G |   6  96   6  96  96   6   6   6
T |  78   0  78   0   0   6  78  78

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: AML-1
CCCCA	PubMed	4l18_E(9.72e-03)
TGGGG	PubMed	4l18_E(9.72e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RGRTVCDCRG--   L                                 +4l0y_A    
                                                 +-1 
  RGRTVCDCRG--   L         +---------------------2 +3wu1_A    
                           !                     ! 
  RGRGVCDCRGRG   L   +-----3                     +-1h9d_A    
                     !     ! 
  KC----------   L --4     +-----------------------1bf5_A    
                     ! 
  ----RT------   L   +-----------------------------1gji_A

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updated Fri Sep 13 18:27:45 2024