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structure nameCRYSTAL STRUCTURE OF HUMAN DUX4 HOMEODOMAINS BOUND TO A12T DNA MUTANT
(Double homeobox protein 4-like protein 4)
referenceGan et al. 'Biochem. 505 1161 2018
sourceHomo sapiens
experimentX-ray (resolution=1.90, R-factor=0.188)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes5z6z_A 5zfw_A 5zfy_A 6e8c_A 6u81_A 6u82_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRIQNRSRRIQNAR

Estimated binding specificities ?

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# IC=11.839 IC/col=0.987 n_of_columns=12 specificity:   
A |   8   0  96  96   0   8   8  24   0   0   0  96
C |  64   0   0   0   8  80  16  24   0   0  96   0
G |  16   0   0   0   0   0  16  24   0   0   0   0
T |   8  96   0   0  88   8  56  24  96  96   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KGRT--IAQCNAYA--RT--------------------   L               +-----------------------------1nk2_P    
                                                         +-1 
  RCRT--NT--NAITRG----------------------               +-2 +-----------------------------5zjt_B    
                                                       ! ! 
  --RT--NT--NAIARG----------------------   L         +-3 +-----------------------------1b72_B    
                                                     ! ! 
  --RTFTYAQTNAATRG----------------------   L       +-4 +-----------------------------6ryd_F    
                                                   ! ! 
  --------------------------RTVAITNAMCRG   L     +-5 +-----------------------------1yrn_A    
                                                 ! ! 
  ------------------RT--RT----IAKGNA----   L   +-6 +-----------------------------6m3d_C    
                                               ! ! 
  --------------------RC--RT--NCSTNARG--   L --7 +-----------------------------1mnm_C    
                                               ! 
  --RA--YAQTNAAARG----------------------   L   +-----------------------------6wig_A    
                                             

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updated Fri Sep 13 21:11:39 2024