6m3d_C : 3D-footprint complex

structure name	X-RAY CRYSTAL STRUCTURE OF TANDEMLY CONNECTED ENGRAILED HOMEODOMAINS (EHD) WITH R53A MUTATIONS AND DNA COMPLEX (SEGMENTATION POLARITY HOMEOBOX PROTEIN ENGRAILED,...)
reference	Sunami et al. 'Acta 76 824 2020
source	DROSOPHILA MELANOGASTER
experiment	X-ray (resolution=1.60, R-factor=0.191)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	1du0_AB 1hdd_CD 2hdd_AB 3hdd_AB
redundant complexes	1du0_A 1hdd_C 2hdd_B 3hdd_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6m3d_C interface=51,53,95,98,99, rtafsseqlarlkrefnenrylterrrqqlsselglneaqikiwfknkaaRpRtafsseqlarlkrefnenrylterrrqqlsselglneaqikIwfKNkaakikksg
interface signature	RRIKN

Estimated binding specificities ?

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# IC=6.195 IC/col=0.885 n_of_columns=7

specificity:

A |   7   7  96  96   9   0   7
C |  73  59   0   0  14  96  68
G |   9   0   0   0   0   0  14
T |   7  30   0   0  73   0   7

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Dendrogram of similar interfaces ?

matrix format

  
  RTRT------IAKGNA------   L                          +-----------6m3d_C    
                                            +---------1 
  KGRT------IAQCNAYA--RT   L             +--2         +-----------1nk2_P    
                                         !  ! 
  --RT------ITQCNAACRG--   L           +-3  +---------------------6a8r_A    
                                       ! ! 
  RCRT------NT--NAITRG--             +-4 +------------------------5zjt_B    
                                     ! ! 
  --RC------IAQCNAYC----   L       +-5 +-------------------------3rkq_B    
                                   ! ! 
  --RTSTVCKGDCRG--------   L     +-6 +--------------------------1w0t_A    
                                 ! ! 
  --RT----FTYAQTNAATRG--   L   +-7 +--------------------------6ryd_F    
                               ! ! 
  --RA----RCVTCTNAQTRC--   L --8 +---------------------------1au7_A    
                               ! 
  --------RTVAITNAMCRG--   L   +---------------------------1yrn_A

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updated Mon Jun 29 23:59:28 2026