6m3d_C : 3D-footprint complex

structure name	X-RAY CRYSTAL STRUCTURE OF TANDEMLY CONNECTED ENGRAILED HOMEODOMAINS (EHD) WITH R53A MUTATIONS AND DNA COMPLEX (SEGMENTATION POLARITY HOMEOBOX PROTEIN ENGRAILED,...)
reference	Sunami et al. 'Acta 76 824 2020
source	DROSOPHILA MELANOGASTER
experiment	X-ray (resolution=1.60, R-factor=0.191)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6m3d_C interface=51,53,95,98,99, rtafsseqlarlkrefnenrylterrrqqlsselglneaqikiwfknkaaRpRtafsseqlarlkrefnenrylterrrqqlsselglneaqikIwfKNkaakikksg
interface signature	RRIKN

Estimated binding specificities ?

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# IC=6.292 IC/col=0.899 n_of_columns=7

specificity:

A |   9   7  96  96   7   0   7
C |  73  73   0   0   7  96  73
G |   7   7   0   0   7   0   9
T |   7   9   0   0  75   0   7

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RTRT------IAKGNA------   L                          +-----------6m3d_C    
                                            +---------1 
  KGRT------IAQCNAYA--RT   L             +--2         +-----------1nk2_P    
                                         !  ! 
  --RT------ITQCNAACRG--   L           +-3  +---------------------6a8r_A    
                                       ! ! 
  RCRT------NT--NAITRG--             +-4 +------------------------5zjt_B    
                                     ! ! 
  --RC------IAQCNAYC----   L       +-5 +-------------------------3rkq_B    
                                   ! ! 
  --RTSTVCKGDCRG--------   L     +-6 +--------------------------1w0t_A    
                                 ! ! 
  --RT----FTYAQTNAATRG--   L   +-7 +--------------------------6ryd_F    
                               ! ! 
  --RA----RCVTCTNAQTRC--   L --8 +---------------------------1au7_A    
                               ! 
  --------RTVAITNAMCRG--   L   +---------------------------1yrn_A

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updated Fri Sep 13 22:35:15 2024