3D-footprint cannot reliably estimate the specificity of histones, as they display few contacts over long stretches of DNA.

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updated Thu Jun 25 16:37:27 2026

structure name	CRYO-EM STRUCTURE OF DOT1L BOUND TO H2B UBIQUITINATED NUCLEOSOME
source	XENOPUS LAEVIS
experiment	NMR
structural superfamily	Histone-fold;P-loop containing nucleoside triphosphate hydrolases;Chromo domain-like;Homeodomain-like;lambda repressor-like DNA-binding domains;p53-like transcription factors;
reference complex	5o9g_F 5o9g_G 5z3o_E 5z3u_A 6fq8_D 6g0l_M 6iro_A 6r25_E 6r8y_H 6x0n_f 7at8_D 7nkx_f 7otq_E 7u0g_M 7vdt_B 7xzx_N 8cww_A 8g57_E 8siy_G
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6jma_A interface=3,28,46, phRyrpgtvalreirryqkstellirkLpfqrlvreiaqdfktdlRfqssavmalqeaseaylvglfedtnlcaihakrvtimpkdiqlarrirgera > 6jma_B interface=25, vlrdniqgitkpairrlarrggvkRisgliyeetrgvlkvflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg > 6jma_C interface= aktrssraglqfpvgrvhrllrkgNyaervgagapvylaavleyltaeilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkkt > 6jma_D interface=2, tRkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtkytsak > 6jma_E interface=3,28,46, phRyrpgtvalreirryqkstellirkLpfqrlvreiaqdfktdlRfqssavmalqeaseaylvglfedtnlcaihakrvtimpkdiqlarrirgera > 6jma_F interface=17,30, krhrkvlrdniqgitkPairrlarrggvkRisgliyeetrgvlkvflenvirdavtytehakrktvtamdvvyalkrqgrtlygfgg > 6jma_G interface= aktrssraglqfpvgrVhrllrkgnyaerVgagapvylaavleyltaeilelagnaardnkktriiprhlqlavrndeelnkllgrvtiaqggvlpniqsvllpkk > 6jma_H interface=2, tRkesyaiyvykvlkqvhpdtgisskamsimnsfvndvferiageasrlahynkrstitsreiqtavrlllpgelakhavsegtkavtkytsak