| structure name | HUMAN DNMT1(729-1600) BOUND TO ZEBULARINE-CONTAINING 12MER DSDNA AND INHIBITOR GSK3830052 (DNA cytosine-5-methyltransferase 1) |
| reference | Horton et al. 'Nat 2 1002 2021 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.79, R-factor=0.201) |
| structural superfamily | S-adenosyl-L-methionine-dependent methyltransferases; |
| sequence family | BAH domain; C5 cytosinespecific DNA methylase; |
| redundant complexes | 3pta 6x9i 6x9k 7sfc 7sfd 7sfe 7sff 7sfg |
| reference complex | 7xi9_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence |
No structural evidence for specific binding to DNA (<4 informative columns)
Dendrogram of similar interfaces ?
matrix format--------------------------CC----HGNA------------MC--KG-- +--------------6x9j_A +---------2 ------------------------DT--YTFT----KT------RG------HTNA ! +--------------7ubu_A +-5 ------------------IT--------------------ECRG------AT---- ! ! +----5ciy_A +-6 +-------------------1 --------------------------------------EG------SCAGNG---- L ! ! +----4dkj_A +-7 ! FTDTITVT--AT----KA--LGIT-------------------------------- L ! ! +--------------------------3zh2_C ! ! ------------------IA------------------------------------ L ! +---------------------------6w8b_A --8 --------NA----YA---------------------------------------- L ! +--------------2ih2_D ! +---------3 ------------FA--KC-------------------------------------- L +---4 +--------------5hr4_C ! --------NA----FA---------------------------------------- +------------------------2y7h_B |
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updated Fri Jan 9 11:29:50 2026