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structure nameSTRUCTURE OF DNMT3A IN COMPLEX WITH CGA DNA
(DNA CYTOSINE-5-METHYLTRANSFERASE 3A)
referenceAnteneh et al. 'Nat 11 2294 2020
sourceHOMO SAPIENS
experimentX-ray (resolution=2.40, R-factor=0.212)
structural superfamilyS-adenosyl-L-methionine-dependent methyltransferases;
sequence familyC5 cytosinespecific DNA methylase 579;
multimeric complexes5yx2_AD 6brr_AD 6w89_AD 6w89_GJ 6w8b_AD 6w8b_HK 6w8d_AD 6w8j_AD
redundant complexes5yx2_A 6brr_A 6f57_A 6w89_A 6w8d_D 6w8j_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureIVPTRSNQ

Estimated binding specificities ?

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# IC=3.249 IC/col=0.812 n_of_columns=4 specificity:   
A |   9   0  96  16
C |   9   0   0  16
G |  69  96   0  19
T |   9   0   0  45
scan!

Dendrogram of similar interfaces ?

matrix format



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updated Sun Aug  3 13:59:26 2025