interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF BACILLUS SUBTILIS HXLR, WILD TYPE IN COMPLEX WITH FORMALDEHYDE AND DNA
(HTH-type transcriptional activator HxlR)
referenceChen et al. 'Nat 12 581 2021
sourceBacillus subtilis (strain 168) / Bacillus subtilis (strain 168)
experimentX-ray (resolution=2.90, R-factor=0.181)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyHxlRlike helixturnhelix;
multimeric complexes7bzg_AB 7bzg_EF 7bzg_IJ
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureFNTQKIVP

Estimated binding specificities ?

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# IC=6.034 IC/col=0.862 n_of_columns=7 specificity:   
A |   0  90   5  80  16   5   5
C |   0   0   5   6  80  10   5
G |  96   6   5   5   0  16  81
T |   0   0  81   5   0  65   5
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----RGSTRTSTHG--------RA--   L                   +---------------3zpl_B    
                                             +-----2 
  --DCLT--AGTTRG--RG----RA--   L             !     !               +5h3r_A    
                                     +-------3     +---------------1 
  ------------RCYG----KT----         !       !                     +2acj_B    
                                   +-4       ! 
  ------KATTQTTGLTRTKA--FTYT   L   ! !       +---------------------2p7c_B    
                                 --5 ! 
  LANTHGTTETYTRG------------   L   ! +-----------------------------1f4k_B    
                                   ! 
  --------------YG----------       +-----------------------------3eyi_B    
                                 

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updated Sat Jan 10 14:28:19 2026