interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF BACILLUS SUBTILIS HXLR, WILD TYPE IN COMPLEX WITH FORMALDEHYDE AND DNA
(HTH-type transcriptional activator HxlR)
referenceChen et al. 'Nat 12 581 2021
sourceBacillus subtilis (strain 168) / Bacillus subtilis (strain 168)
experimentX-ray (resolution=2.90, R-factor=0.181)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyHxlRlike helixturnhelix;
multimeric complexes7bzg_AB 7bzg_EF 7bzg_IJ
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureFNTQKIVP

Estimated binding specificities ?

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# IC=4.892 IC/col=0.699 n_of_columns=7 specificity:   
A |   9  24   0   9  75   9   0
C |  75  24   0   6   6   6  96
G |   6  24  90   6   9   6   0
T |   6  24   6  75   6  75   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----RGSTRTSTHG------RA----   L           +-----------------------------3zpl_B    
                                         +-1 
  ------KATTQTTGLTRTKAFT--YT   L       +-2 +-----------------------------2p7c_B    
                                       ! ! 
  LANTHGTTETYTRG------------   L     +-3 +-----------------------------1f4k_B    
                                     ! ! 
  --SG--PTPGTT----------HG--   L   +-4 +-----------------------------7d98_Q    
                                   ! ! 
  --DCLT--AGTTRG--RG--RA----   L --5 +-----------------------------5h3r_A    
                                   ! 
  --------------YG----------       +-----------------------------3eyi_B

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updated Sun Aug 3 15:44:33 2025