interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF BACILLUS SUBTILIS HXLR, WILD TYPE IN COMPLEX WITH FORMALDEHYDE AND DNA
(HTH-type transcriptional activator HxlR)
referenceChen et al. 'Nat 12 581 2021
sourceBacillus subtilis (strain 168) / Bacillus subtilis (strain 168)
experimentX-ray (resolution=2.90, R-factor=0.181)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyHxlRlike helixturnhelix;
multimeric complexes7bzg_AB 7bzg_EF 7bzg_IJ
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureFNTQKIVP

Estimated binding specificities ?

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# IC=6.154 IC/col=0.879 n_of_columns=7 specificity:   
A |   0  84   0  90   6  12  12
C |   0   0  12   6  90   6   0
G |  96  12  12   0   0  30  78
T |   0   0  72   0   0  48   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----RGSTRTSTHG--------RA--   L                   +---------------3zpl_B    
                                             +-----2 
  --DCLT--AGTTRG--RG----RA--   L             !     !               +5h3r_A    
                                     +-------3     +---------------1 
  ------------RCYG----KT----         !       !                     +2acj_B    
                                   +-4       ! 
  ------KATTQTTGLTRTKA--FTYT   L   ! !       +---------------------2p7c_B    
                                 --5 ! 
  LANTHGTTETYTRG------------   L   ! +-----------------------------1f4k_B    
                                   ! 
  --------------YG----------       +-----------------------------3eyi_B    
                                 

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updated Tue Jun 30 04:20:09 2026